Institute of Human Nutrition and Food Science, Christian-Albrechts-University Kiel, Hermann-Rodewald-Straße 6-8, D-24118 Kiel, Germany.
Food Chem Toxicol. 2013 Aug;58:255-63. doi: 10.1016/j.fct.2013.04.046. Epub 2013 May 1.
The process of ageing has been repeatedly associated with increasing oxidative damage which has led to the hypothesis that reducing oxidative stress through antioxidant dietary factors may prolong lifespan. Ascorbic acid is an essential antioxidant in human diets and is widely used for supplementation. However, it is rather unclear if and to what extent ascorbic acid may affect lifespan in humans and model organisms. In our review of literature on vitamin C supplementation and its effect on lifespan in different model organisms we found that some studies suggest an increase in lifespan, other studies failed to observe any beneficial effect of vitamin C on longevity and some studies even reported a decrease in lifespan following vitamin C supplementation. Of the 14 studies included in our analysis, three were carried out in worms, four in flies and seven in rodents. The discrepancies between the studies may be related to species-specific differences, the concentration of vitamin C administered, the duration of supplementation and whether vitamin C was used alone or as part of a combined antioxidant diet. Potential underlying mechanisms through which vitamin C may influence lifespan and differences amongst species regarding the capacity to produce vitamin C endogenously are discussed.
衰老过程与氧化损伤的增加有关，这导致了通过抗氧化饮食因素来减少氧化应激可能延长寿命的假设。抗坏血酸是人类饮食中的一种必需抗氧化剂，广泛用于补充。然而，抗坏血酸是否以及在何种程度上可能影响人类和模式生物的寿命还不是很清楚。在我们对维生素 C 补充及其对不同模式生物寿命影响的文献综述中，我们发现一些研究表明寿命延长，其他研究未能观察到维生素 C 对长寿有任何有益影响，一些研究甚至报告说维生素 C 补充后寿命缩短。在我们分析的 14 项研究中，有 3 项在蠕虫中进行，4 项在果蝇中进行，7 项在啮齿动物中进行。研究之间的差异可能与物种特异性差异、给予的维生素 C 浓度、补充的持续时间以及维生素 C 是否单独使用或作为联合抗氧化饮食的一部分有关。讨论了维生素 C 可能影响寿命的潜在机制以及物种之间内源性产生维生素 C 的能力的差异。
