Yu Guixiang, Liu Shaowei, Yang Kun, Wu Qi
Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Central Nervous System Drug Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.
Front Nutr. 2023 Oct 24;10:1277715. doi: 10.3389/fnut.2023.1277715. eCollection 2023.
B vitamins constitute essential micronutrients in animal organisms, executing crucial roles in numerous biological processes. B vitamin deficiency can result in severe health consequences, including the impairment of reproductive functions and increased susceptibility to age-related diseases. However, the understanding of how reproduction alters the requirements of each individual B vitamins for healthy aging and lifespan remains limited. Here, utilizing as a model organism, we revealed the substantial impacts of deficiencies in specific B vitamins on lifespan and diverse physiological functions, with the effects being significantly shaped by reproductive status. Notably, the dietary absence of VB, VB, VB, VB, or VB significantly decreased the lifespan of wild-type females, yet demonstrated relatively little effect on infertile mutant females' lifespan. B vitamin deficiencies also resulted in distinct impacts on the reproduction, starvation tolerance and fat metabolism of wild-type females, though no apparent effects were observed in the infertile mutant females. Moreover, a deficiency in VB reshaped the impacts of macronutrient intervention on the physiology and lifespan of fertile females in a reproductive-dependent manner. Overall, our study unravels that the reproductive status of females serves as a critical modulator of the lifespan and physiological alterations elicited by B-vitamin deficiencies.
B族维生素是动物机体必需的微量营养素，在众多生物过程中发挥着关键作用。B族维生素缺乏会导致严重的健康后果，包括生殖功能受损以及对与年龄相关疾病的易感性增加。然而，对于生殖如何改变每种B族维生素对健康衰老和寿命的需求的理解仍然有限。在这里，我们以[具体模型生物未给出]作为模式生物，揭示了特定B族维生素缺乏对寿命和多种生理功能的重大影响，这些影响受到生殖状态的显著影响。值得注意的是，饮食中缺乏VB1、VB2、VB6、VB9或VB12会显著缩短野生型雌性的寿命，但对不育突变雌性的寿命影响相对较小。B族维生素缺乏对野生型雌性的生殖、饥饿耐受性和脂肪代谢也产生了不同的影响，不过在不育突变雌性中未观察到明显影响。此外，VB6缺乏以生殖依赖的方式重塑了常量营养素干预对可育雌性生理和寿命的影响。总体而言，我们的研究揭示了雌性的生殖状态是B族维生素缺乏引起的寿命和生理变化的关键调节因素。
