Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, 27695-7910, USA.
Comput Biol Med. 2012 Dec;42(12):1196-203. doi: 10.1016/j.compbiomed.2012.09.011. Epub 2012 Oct 23.
This paper develops a transient three-kinetic state model that simulates rerouting of a pulse of axonal cargos that were initially misdirected to a dendrite. The following three cargo populations are included in the model: (i) anterogradely running cargos, (ii) retrogradely running cargos, and (iii) free (diffusion-driven) cargos that are detached from microtubules. The dynamics of cargo concentrations in various kinetic states are studied. It is demonstrated that the profile of the total cargo concentration is comprised of two major components. The first component is a pulse composed of anterogradely running cargos and the second component is a tail behind this pulse that is composed of free (diffusion-driven) and retrogradely running cargos. The total number of misdirected axonal cargos in the dendrite is also computed. The dependence of this quantity on the amount of time that passed from the moment when the pulse entered the dendrite and on kinetic constants describing transition rates between various kinetic states of misdirected cargos is investigated.
本文开发了一个瞬态三动力学状态模型，用于模拟最初被误导向树突的轴突货物脉冲的重新路由。该模型包括以下三种货物群体：（i）顺向运行的货物，（ii）逆向运行的货物，以及（iii）与微管分离的自由（扩散驱动）货物。研究了各种动力学状态下货物浓度的动态。结果表明，总货物浓度的分布由两个主要成分组成。第一个成分是由顺向运行的货物组成的脉冲，第二个成分是该脉冲后面的尾部，由自由（扩散驱动）和逆向运行的货物组成。还计算了错误导向树突中的总轴突货物数量。研究了此数量与脉冲进入树突的时间以及描述错误导向货物各种动力学状态之间的跃迁速率的动力学常数之间的关系。
