Department of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC 27695-7910, USA.
Int J Numer Method Biomed Eng. 2013 Mar;29(3):428-43. doi: 10.1002/cnm.2521. Epub 2012 Oct 18.
The purpose of this paper is to develop a three-kinetic state model to investigate axonal cargo rerouting in a dendrite. It is assumed that axonal cargos are transported by kinesin motors; they can enter dendrites riding on plus-end-out microtubules (MTs). If this happens, cargos are rerouted by dissociating from these MTs and associating with minus-end-out MTs. The same kinesin motors then move axonal cargos out of the dendrite. The model predicts how far axonal cargos can penetrate into the dendrite, concentrations of various populations of axonal cargos, and cargo fluxes.
本文旨在建立一个三动力学状态模型，以研究树突中轴突货物的改道。假设轴突货物由驱动蛋白马达运输；它们可以通过附着在正极伸出的微管（MTs）上进入树突。如果发生这种情况，货物会从这些 MT 上解离，并与负极伸出的 MT 结合，从而被改道。同样的驱动蛋白马达随后将轴突货物移出树突。该模型预测了轴突货物能深入树突的距离、各种轴突货物群体的浓度以及货物通量。
