Banet M, Brandt S
Institute for Normal and Pathological Physiology, Philipps University, Marburg, Federal Republic of Germany.
Am J Physiol. 1990 Feb;258(2 Pt 2):R393-7. doi: 10.1152/ajpregu.1990.258.2.R393.
To clarify the mechanism of the stimulating effect of fever on the primary antibody response, rats were immunized with sheep erythrocytes, and a fever-like response was induced by cooling the preoptic area for five days. Diazepam, 0.5 mg/kg, given daily during the cooling time, did not affect the normal antibody response of the control animals nor did it prevent the rise in body temperature elicited by cooling the preoptic area but it did, nevertheless, strongly reduce the stimulating effect of this procedure on antibody production. A smaller reduction of this effect was also seen in adrenalectomized rats in which a physiological and stable plasma level of corticosterone was maintained. Because diazepam suppresses some sympathetic and endocrine responses to stress, these data suggest that the effect of cooling the preoptic area on the primary antibody response, and, by inference, that of fever, is to a large extent mediated by the adrenal and other stress response or responses to the cold stimulus. The results do not, however, exclude the possibility of an additional, direct effect of the elevated body temperature on immunocompetent cells.
为阐明发热对初次抗体反应的刺激机制，用绵羊红细胞对大鼠进行免疫，并通过冷却视前区五天诱导出类似发热的反应。在冷却期间每天给予0.5毫克/千克的地西泮，既不影响对照动物的正常抗体反应，也不能阻止因冷却视前区引起的体温升高，但它确实能强烈降低该程序对抗体产生的刺激作用。在维持生理稳定的皮质酮血浆水平的肾上腺切除大鼠中，也观察到这种作用的较小程度的降低。由于地西泮会抑制一些对应激的交感和内分泌反应，这些数据表明，冷却视前区对初次抗体反应的作用，以及由此推断的发热的作用，在很大程度上是由肾上腺和其他应激反应或对冷刺激的反应介导的。然而，这些结果并不排除体温升高对免疫活性细胞有额外直接作用的可能性。
