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标准静脉注射免疫球蛋白用于原发性巨细胞病毒感染孕妇的安全性和有效性的初步评估。

Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.

作者信息

Polilli Ennio, Parruti Giustino, D'Arcangelo Francesca, Tracanna Elisa, Clerico Luigi, Savini Vincenzo, D'Antonio Francesco, Rosati Maurizio, Manzoli Lamberto, D'Antonio Domenico, Nigro Giovanni

机构信息

Microbiology and Virology Unit, General Hospital of Pescara, Pescara, Italy.

出版信息

Clin Vaccine Immunol. 2012 Dec;19(12):1991-3. doi: 10.1128/CVI.00509-12. Epub 2012 Oct 24.

DOI:10.1128/CVI.00509-12
PMID:23100477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535874/
Abstract

Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.

摘要

据报道，高效免疫球蛋白可预防和治疗孕期胎儿巨细胞病毒（CMV）感染。在此，我们报告，输注标准人静脉注射免疫球蛋白可显著提高孕妇的CMV IgG滴度和亲和力指数，为将母体CMV体液免疫被动转移至胎儿的应用铺平了道路。前67例新生儿围产期结局的初步数据令人鼓舞。

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Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age.妊娠早期巨细胞病毒原发性感染：母体高免疫球蛋白治疗可改善婴儿 1 岁时的结局。
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Immunoglobulin therapy of fetal cytomegalovirus infection occurring in the first half of pregnancy--a case-control study of the outcome in children.妊娠早中期巨细胞病毒感染的免疫球蛋白治疗——一项儿童结局的病例对照研究。
J Infect Dis. 2012 Jan 15;205(2):215-27. doi: 10.1093/infdis/jir718. Epub 2011 Dec 2.
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