标准静脉注射免疫球蛋白用于原发性巨细胞病毒感染孕妇的安全性和有效性的初步评估。
Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.
作者信息
Polilli Ennio, Parruti Giustino, D'Arcangelo Francesca, Tracanna Elisa, Clerico Luigi, Savini Vincenzo, D'Antonio Francesco, Rosati Maurizio, Manzoli Lamberto, D'Antonio Domenico, Nigro Giovanni
机构信息
Microbiology and Virology Unit, General Hospital of Pescara, Pescara, Italy.
出版信息
Clin Vaccine Immunol. 2012 Dec;19(12):1991-3. doi: 10.1128/CVI.00509-12. Epub 2012 Oct 24.
Abstract
Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.
摘要
据报道，高效免疫球蛋白可预防和治疗孕期胎儿巨细胞病毒（CMV）感染。在此，我们报告，输注标准人静脉注射免疫球蛋白可显著提高孕妇的CMV IgG滴度和亲和力指数，为将母体CMV体液免疫被动转移至胎儿的应用铺平了道路。前67例新生儿围产期结局的初步数据令人鼓舞。
相似文献
1
Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.标准静脉注射免疫球蛋白用于原发性巨细胞病毒感染孕妇的安全性和有效性的初步评估。
Clin Vaccine Immunol. 2012 Dec;19(12):1991-3. doi: 10.1128/CVI.00509-12. Epub 2012 Oct 24.
2
[Therapy or prevention of fetal infection by cytomegalovirus with immunoglobulin infusion in pregnant women with primary infection].[通过对初次感染的孕妇输注免疫球蛋白治疗或预防巨细胞病毒胎儿感染]
Acta Biomed Ateneo Parmense. 2000;71 Suppl 1:547-51.
3
Prevention and treatment of fetal cytomegalovirus infection with cytomegalovirus hyperimmune globulin: a multicenter study in Madrid.巨细胞病毒高效价免疫球蛋白预防和治疗胎儿巨细胞病毒感染：马德里的一项多中心研究
J Matern Fetal Neonatal Med. 2019 Feb;32(4):617-625. doi: 10.1080/14767058.2017.1387890. Epub 2017 Oct 26.
4
Passive immunization during pregnancy for congenital cytomegalovirus infection.孕期针对先天性巨细胞病毒感染的被动免疫
N Engl J Med. 2005 Sep 29;353(13):1350-62. doi: 10.1056/NEJMoa043337.
5
Properties and mechanisms of immunoglobulins for congenital cytomegalovirus disease.先天性巨细胞病毒病的免疫球蛋白特性与机制。
Clin Infect Dis. 2013 Dec;57 Suppl 4:S185-8. doi: 10.1093/cid/cit584.
6
[The first hyperimmune immunoglobulin against cytomegaloviruses made in the Czech Republic].[捷克共和国制造的第一种抗巨细胞病毒的高免疫球蛋白]
Cas Lek Cesk. 1993 Sep 13;132(17):532-4.
7
A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.巨细胞病毒免疫球蛋白预防先天性巨细胞病毒感染的临床试验
N Engl J Med. 2021 Jul 29;385(5):436-444. doi: 10.1056/NEJMoa1913569.
8
Primary maternal cytomegalovirus infections during pregnancy: association of CMV hyperimmune globulin with gestational age at birth and birth weight.孕期原发性巨细胞病毒感染：巨细胞病毒高效价免疫球蛋白与出生孕周及出生体重的关联
J Matern Fetal Neonatal Med. 2015 Jan;28(2):168-71. doi: 10.3109/14767058.2014.907265. Epub 2014 Apr 25.
9
Dilemmas regarding the use of CMV-specific immunoglobulin in pregnancy.孕期使用巨细胞病毒特异性免疫球蛋白的相关困境。
J Clin Virol. 2013 Jun;57(2):95-7. doi: 10.1016/j.jcv.2012.12.007. Epub 2013 Jan 11.
10
A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus.巨细胞病毒免疫球蛋白预防先天性巨细胞病毒感染的随机试验。
N Engl J Med. 2014 Apr 3;370(14):1316-26. doi: 10.1056/NEJMoa1310214.
引用本文的文献
1
Is Neonatal Viremia a Possible Predictor of the Timing of Maternal Infection in Asymptomatic Congenital Cytomegalovirus Infection? A Retrospective Study.新生儿病毒血症是否是无症状先天性巨细胞病毒感染中母体感染时间的潜在预测指标？一项回顾性研究。
J Pers Med. 2025 Apr 24;15(5):165. doi: 10.3390/jpm15050165.
2
Early detection of active Human CytomegaloVirus (hCMV) infection in pregnant women using data generated for noninvasive fetal aneuploidy testing.利用非侵入性胎儿非整倍体检测产生的数据早期检测孕妇的人巨细胞病毒（hCMV）活动性感染。
EBioMedicine. 2024 Feb;100:104983. doi: 10.1016/j.ebiom.2024.104983. Epub 2024 Feb 2.
3
T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients.T细胞亚群和免疫球蛋白G水平与系统性红斑狼疮患者的感染状况相关。
Braz J Med Biol Res. 2017 Dec 11;51(2):e4547. doi: 10.1590/1414-431X20154547.
4
Post-traumatic stress in pregnant women with primary cytomegalovirus infection and risk of congenital infection in newborns.原发性巨细胞病毒感染孕妇的创伤后应激与新生儿先天性感染风险
BJPsych Open. 2016 Nov 24;2(6):373-376. doi: 10.1192/bjpo.bp.116.003152. eCollection 2016 Nov.
5
Impact of Antibodies and Strain Polymorphisms on Cytomegalovirus Entry and Spread in Fibroblasts and Epithelial Cells.抗体和毒株多态性对巨细胞病毒进入及在成纤维细胞和上皮细胞中传播的影响
J Virol. 2017 Jun 9;91(13). doi: 10.1128/JVI.01650-16. Print 2017 Jul 1.
6
In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539.靶向人巨细胞病毒的治疗性单克隆抗体LJP538和LJP539的体外特性研究
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4961-71. doi: 10.1128/AAC.00382-16. Print 2016 Aug.
7
The immunological underpinnings of vaccinations to prevent cytomegalovirus disease.预防巨细胞病毒疾病的疫苗接种的免疫学基础。
Cell Mol Immunol. 2015 Mar;12(2):170-9. doi: 10.1038/cmi.2014.120. Epub 2014 Dec 29.
8
Cytomegalovirus in the neonate: immune correlates of infection and protection.新生儿巨细胞病毒感染：感染与保护的免疫关联
Clin Dev Immunol. 2013;2013:501801. doi: 10.1155/2013/501801. Epub 2013 Aug 19.
9
Cytomegalovirus vaccine strain towne-derived dense bodies induce broad cellular immune responses and neutralizing antibodies that prevent infection of fibroblasts and epithelial cells.巨细胞病毒疫苗株 Towne 衍生的致密体诱导广泛的细胞免疫应答和中和抗体，可预防成纤维细胞和上皮细胞感染。
J Virol. 2013 Oct;87(20):11107-20. doi: 10.1128/JVI.01554-13. Epub 2013 Aug 7.
10
Cytomegalovirus in pregnancy: to screen or not to screen.妊娠巨细胞病毒：筛查还是不筛查。
BMC Pregnancy Childbirth. 2013 Apr 18;13:96. doi: 10.1186/1471-2393-13-96.
本文引用的文献
1
Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis.使用巨细胞病毒高免疫球蛋白预防先天性巨细胞病毒病：回顾性分析。
J Perinat Med. 2012 Mar 27;40(4):439-46. doi: 10.1515/jpm-2011-0257.
2
Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age.妊娠早期巨细胞病毒原发性感染：母体高免疫球蛋白治疗可改善婴儿 1 岁时的结局。
Clin Infect Dis. 2012 Aug;55(4):497-503. doi: 10.1093/cid/cis423. Epub 2012 Apr 26.
3
Immunoglobulin therapy of fetal cytomegalovirus infection occurring in the first half of pregnancy--a case-control study of the outcome in children.妊娠早中期巨细胞病毒感染的免疫球蛋白治疗——一项儿童结局的病例对照研究。
J Infect Dis. 2012 Jan 15;205(2):215-27. doi: 10.1093/infdis/jir718. Epub 2011 Dec 2.
4
Comparative evaluation of three automated systems for DNA extraction in conjunction with three commercially available real-time PCR assays for quantitation of plasma Cytomegalovirus DNAemia in allogeneic stem cell transplant recipients.三种自动化 DNA 提取系统与三种商业化实时 PCR 检测方法联合检测异基因造血干细胞移植受者血浆巨细胞病毒 DNA 血症的比较评估。
J Clin Microbiol. 2011 Aug;49(8):2899-904. doi: 10.1128/JCM.00785-11. Epub 2011 Jun 22.
5
Cytomegalovirus neutralization by hyperimmune and standard intravenous immunoglobulin preparations.巨细胞病毒中和作用的高免疫和标准静脉注射免疫球蛋白制剂。
Transplantation. 2011 Aug 15;92(3):267-70. doi: 10.1097/TP.0b013e318224115e.
6
Intravenous immunoglobulins in immunodeficiencies: more than mere replacement therapy.静脉注射免疫球蛋白在免疫缺陷中的应用：不仅仅是替代疗法。
Clin Exp Immunol. 2011 Jun;164 Suppl 2(Suppl 2):2-5. doi: 10.1111/j.1365-2249.2011.04387.x.
7
Findings and conclusions from CMV hyperimmune globulin treatment trials.CMV 高免疫球蛋白治疗试验的结果和结论。
J Clin Virol. 2009 Dec;46 Suppl 4:S54-7. doi: 10.1016/j.jcv.2009.08.017. Epub 2009 Sep 24.
8
The value of immunoprophylaxis for cytomegalovirus infection with intravenous immunoglobulin in pediatric liver transplant recipients receiving a low-dose immunosupressive regimen.
Pediatr Transplant. 2010 Feb;14(1):67-71. doi: 10.1111/j.1399-3046.2008.01120.x. Epub 2009 Jan 18.
9
A newer immunoglobulin intravenous (IGIV) - Gammagard liquid 10%: evaluation of efficacy, safety, tolerability and impact on patient care.一种新型静脉注射免疫球蛋白（IGIV）——10%液体剂型的伽玛莱士：疗效、安全性、耐受性及对患者护理影响的评估
Expert Opin Biol Ther. 2008 Jun;8(6):799-804. doi: 10.1517/14712598.8.6.799.
10
Relationship of IgG avidity index and IgM levels for the differential diagnosis of primary from recurrent cytomegalovirus infections.
Iran J Allergy Asthma Immunol. 2007 Dec;6(4):197-201.
Zotero 插件