Infectious Disease Unit.
Clin Infect Dis. 2013 Dec;57 Suppl 4:S185-8. doi: 10.1093/cid/cit584.
Immunoglobulins are one major component of adaptive immunity to external and resident microorganisms, evolving very early in phylogenesis. They help eukaryotes in controlling infections, mainly through their neutralizing activity, which quenches both the cytopathic and inflammatory potential of invading microorganisms. Cytomegalovirus (CMV)-related disease is generally blunted in seropositive subjects with conserved specific humoral responses. CMV-seropositive pregnant women, in accordance with such evidence, suffer little or no fetal damage when reexposed to CMV. Several seminal experiences and early experimental models confirmed that repeated infusions of immunoglobulins, either with hyperimmune or standard preparations, may help to reduce maternal-fetal CMV transmission, as well as to quench fetal disease upon transmission. This review focused on experimental evidence supporting the potential role of immunoglobulins as a tool to control fetal CMV-related disease in pregnant women.
免疫球蛋白是适应性免疫对外来和常驻微生物的主要成分之一，在进化过程中很早就出现了。它们通过中和作用帮助真核生物控制感染，中和作用既能抑制入侵微生物的细胞病变和炎症潜能。在具有保守特异性体液反应的血清阳性者中，巨细胞病毒（CMV）相关疾病通常较轻。根据这些证据，CMV 血清阳性的孕妇在再次接触 CMV 时几乎不会或不会对胎儿造成损害。一些开创性的经验和早期的实验模型证实，反复输注免疫球蛋白，无论是使用高免疫球蛋白还是标准制剂，都可能有助于降低母婴 CMV 传播，以及在传播时抑制胎儿疾病。这篇综述重点介绍了支持免疫球蛋白作为控制孕妇 CMV 相关疾病的工具的潜在作用的实验证据。
