• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
A combined vaccine against Brucella abortus and infectious bovine rhinotracheitis.布鲁氏菌流产亚种和牛传染性鼻气管炎联合疫苗。
Indian J Microbiol. 2009 Jun;49(2):161-8. doi: 10.1007/s12088-009-0028-7. Epub 2009 Jun 3.
2
Non-infectious outer membrane vesicles derived from Brucella abortus S19Δper as an alternative acellular vaccine protects mice against virulent challenge.源自布鲁氏菌 abortus S19Δper 的无感染性外膜囊泡作为一种替代的非细胞疫苗，可保护小鼠免受强毒攻击。
Int Immunopharmacol. 2021 Jan;90:107148. doi: 10.1016/j.intimp.2020.107148. Epub 2020 Nov 12.
3
Immunization with S19Δ Conferred Protection in Water Buffaloes against Virulent Challenge with Strain S544.用S19Δ免疫水牛可使其免受S544毒株的强毒攻击。
Vaccines (Basel). 2021 Dec 2;9(12):1423. doi: 10.3390/vaccines9121423.
4
Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of Brucella abortus.用流产布鲁氏菌突变株对牛进行实验性疫苗接种后的免疫反应及对感染和流产的保护作用。
Am J Vet Res. 1993 Oct;54(10):1591-7.
5
A combined DNA vaccine provides protective immunity against Mycobacterium bovis and Brucella abortus in cattle.一种联合DNA疫苗可使牛对牛分枝杆菌和布鲁氏菌流产亚种产生保护性免疫。
DNA Cell Biol. 2009 Apr;28(4):191-9. doi: 10.1089/dna.2008.0790.
6
Recombinant bovine interleukin 2 enhances immunity and protection induced by Brucella abortus vaccines in cattle.重组牛白细胞介素2增强牛流产布鲁氏菌疫苗诱导的免疫力和保护作用。
Vet Microbiol. 2005 Nov 30;111(1-2):77-87. doi: 10.1016/j.vetmic.2005.09.004. Epub 2005 Oct 19.
7
Immune Response of Calves Vaccinated with Brucella abortus S19 or RB51 and Revaccinated with RB51.用布鲁氏菌流产亚种S19或RB51疫苗接种并再次用RB51疫苗接种的犊牛的免疫反应
PLoS One. 2015 Sep 9;10(9):e0136696. doi: 10.1371/journal.pone.0136696. eCollection 2015.
8
Immunoproteomics of Brucella abortus reveals potential of recombinant antigens for discriminating vaccinated from naturally infected cattle.布鲁氏菌属免疫蛋白质组学揭示了重组抗原区分接种疫苗牛和自然感染牛的潜力。
Microb Pathog. 2020 Oct;147:104345. doi: 10.1016/j.micpath.2020.104345. Epub 2020 Jun 13.
9
A rapid cycleave PCR method for distinguishing the vaccine strain Brucella abortus A19 in China.一种用于鉴别中国疫苗株流产布鲁氏菌A19的快速循环ave PCR方法。 （注：原文中“cycleave”可能有误，推测可能是“cycleave”，但按正确的“cycleave”翻译较难理解其确切含义，推测为“cycleave”有误，若为“real-time”即实时，那么译文为：一种用于鉴别中国疫苗株流产布鲁氏菌A19的快速实时PCR方法 ）
J Vet Diagn Invest. 2016 May;28(3):214-8. doi: 10.1177/1040638716640315. Epub 2016 Apr 13.
10
The effect of challenge with virulent Brucella abortus on beef cattle vaccinated as calves or adults with either Brucella abortus strain 19 or 45/20.用强毒流产布鲁氏菌攻击对犊牛或成年牛接种流产布鲁氏菌19株或45/20株疫苗后的影响。
Aust Vet J. 1981 Oct;57(10):470-3. doi: 10.1111/j.1751-0813.1981.tb05769.x.

本文引用的文献

1
Duration of immunity of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV, and BRSV in experimentally infected calves.一种四价疫苗对实验性感染小牛中由牛疱疹病毒1型、副流感病毒3型、牛病毒性腹泻病毒和牛呼吸道合胞体病毒引起的呼吸道疾病的免疫持续时间。
Prev Vet Med. 2004 Dec 15;66(1-4):63-77. doi: 10.1016/j.prevetmed.2004.08.001.
2
Rough vaccines in animal brucellosis: structural and genetic basis and present status.动物布鲁氏菌病的粗糙型疫苗：结构与遗传基础及现状
Vet Res. 2004 Jan-Feb;35(1):1-38. doi: 10.1051/vetres:2003037.
3
Antibody dynamics in Holstein Friesian heifers vaccinated with Brucella abortus strain 19, using seven serological tests.使用七种血清学检测方法，对接种布鲁氏菌19号菌株的荷斯坦弗里生小母牛的抗体动态进行研究。
J Immunoassay Immunochem. 2002;23(4):471-8. doi: 10.1081/ias-120015478.
4
Fluorescence polarization assay for the diagnosis of brucellosis: a review.用于布鲁氏菌病诊断的荧光偏振测定法：综述
J Immunoassay Immunochem. 2001;22(3):183-201. doi: 10.1081/IAS-100104705.
5
Serologic responses in diagnostic tests for brucellosis in cattle vaccinated with Brucella abortus 19 or RB51.用流产布鲁氏菌19或RB51疫苗接种的牛布鲁氏菌病诊断试验中的血清学反应。
J Clin Microbiol. 1994 Apr;32(4):1065-6. doi: 10.1128/jcm.32.4.1065-1066.1994.
6
Evaluation of inactivated infectious bovine rhinotracheitis vaccines.灭活传染性牛鼻气管炎疫苗的评估
Can J Comp Med. 1975 Oct;39(4):402-5.

布鲁氏菌流产亚种和牛传染性鼻气管炎联合疫苗。

A combined vaccine against Brucella abortus and infectious bovine rhinotracheitis.

机构信息

Indian Immunologicals Limited, Hyderabad, Andhra Pradesh India.

出版信息

Indian J Microbiol. 2009 Jun;49(2):161-8. doi: 10.1007/s12088-009-0028-7. Epub 2009 Jun 3.

DOI:10.1007/s12088-009-0028-7
PMID:23100765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3450140/
Abstract

The present study was undertaken to study the immune response in calves vaccinated with Brucella abortus strain 19, infectious bovine rhinotracheitis (IBR) vaccines in monovalent form and combined vaccine containing both antigen. The seroconversion of monovalent and combined vaccines was tested in seronegative cattle calves. IBR vaccine alone and combination with live Brucella abortus S19 vaccine elicited an anamnestic response on day 60 post booster but started declining from day 90 onwards against IBR. B. abortus S19 alone and in combination with IBR vaccine gave more than 2 log protection in mice two weeks post challenge. Fluorescence polarization assay analysis with sera samples of calves vaccinated with B. abortus S19 monovalent vaccine alone and in combination with IBR vaccine revealed the presence of B. abortus antibodies. The components of the combined vaccine did not show any evidence of interference in the development of immunity. This combined vaccine may provide economical and affordable biological for the control of brucellosis and IBR.

摘要

本研究旨在研究用布氏杆菌 19 株、传染性牛鼻气管炎（IBR）单价疫苗和含有两种抗原的联合疫苗接种小牛的免疫反应。在血清阴性的小牛中测试了单价和联合疫苗的血清转化率。单独使用 IBR 疫苗和与活布鲁氏菌 S19 疫苗联合使用在加强后第 60 天引起了回忆反应，但从第 90 天开始对 IBR 的反应开始下降。单独使用布鲁氏菌 S19 以及与 IBR 疫苗联合使用，在挑战后两周可使小鼠获得超过 2 个对数的保护。用单独接种布鲁氏菌 S19 单价疫苗和联合接种 IBR 疫苗的小牛血清样本进行荧光偏振分析显示存在布鲁氏菌抗体。联合疫苗的成分没有显示出对免疫发展的任何干扰证据。这种联合疫苗可能为控制布鲁氏菌病和 IBR 提供经济实惠的生物制剂。