MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow, G11 5JR UK.
Indian J Microbiol. 2009 Dec;49(4):352-7. doi: 10.1007/s12088-009-0062-5. Epub 2010 Jan 7.
Recent advances in phylogenetic methods have produced some reassessments of the ages of the most recent common ancestor of hemagglutinin proteins in known strains of influenza A. This paper applies Bayesian phylogenetic analysis implemented in BEAST to date the nodes on the influenza A hemagglutinin tree. The most recent common ancestor (MRCA) of influenza A hemagglutinin proteins is located with 95% confidence between 517 and 1497 of the Common Era (AD), with the center of the probability distribution at 1056 AD. The implications of this revised dating for both historical and current epidemiology are discussed. Influenza A can be seen as an emerging disease of mediaeval and early modern times.
近年来，系统发育方法的进展对已知流感 A 株血凝素蛋白最接近共同祖先的年代进行了一些重新评估。本文应用 BEAST 中实现的贝叶斯系统发育分析来确定流感 A 血凝素树的节点日期。流感 A 血凝素蛋白的最接近共同祖先（MRCA）位于公元 517 年至 1497 年之间，置信区间为 95%，概率分布中心位于公元 1056 年。这一修正的约会对历史和当前流行病学都有影响。可以将流感 A 视为中世纪和近代新兴的疾病。
