Universidade de Aveiro, Departamento de Física, 3810-193 Aveiro, Portugal.
Sci Rep. 2012;2:769. doi: 10.1038/srep00769. Epub 2012 Oct 25.
It is still unclear whether the adaptive immune system can perform accurate self-nonself discrimination and what could influence its performance. Starting from simple cellular interaction rules we show that it is possible to achieve perfect self-nonself discrimination in a consistent framework provided positive and negative selection operate during repertoire education, and costimulation and anergy are also considered during T cell activation. In this theory T cell receptors diversity is required for cells to sense differently different peptides; positive selection is needed to guarantee maximal lymphocyte's interactivity and to allow negative selection to reduce conjugation lifetimes maximally; costimulation is necessary to signal that an antigen presenting cell established an uncommon rate of long lived conjugations when presenting foreign peptides; anergy is required to guarantee that these stable contacts involved different T cells and not always the same. These results suggest that accurate self-nonself discrimination can have shaped the adaptive immune system.
目前尚不清楚适应性免疫系统是否能够进行准确的自我-非自我识别，以及哪些因素会影响其性能。从简单的细胞相互作用规则出发，我们表明，在正选择和负选择在库教育过程中起作用，并且在 T 细胞激活过程中考虑共刺激和失能的情况下，在一致的框架内实现完美的自我-非自我识别是有可能的。在这个理论中，T 细胞受体的多样性是细胞感知不同肽的差异所必需的；正选择是必需的，以保证淋巴细胞的最大相互作用，并允许负选择将共轭寿命最大程度地降低；共刺激是必需的，以表明当呈现外来肽时，抗原呈递细胞建立了不同的、长寿的共轭的不常见速率；失能是必需的，以保证这些稳定的接触涉及不同的 T 细胞，而不是总是相同的。这些结果表明，准确的自我-非自我识别可能已经塑造了适应性免疫系统。
