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[克罗恩病:42例肠道切除术的系列结果]

[Crohn disease: results of a series of 42 intestinal resections].

作者信息

Leblanc I, Bokobza B, Michot F, Ténière P

机构信息

Service de Chirurgie Générale et Digestive, Hôtel-Dieu, Rouen.

出版信息

Ann Chir. 1990;44(1):30-3.

PMID:2310143
Abstract

Forty-two patients underwent a resection for acute or chronic complications of Crohn's disease during the years 1983-1987. The colon was involved in 38% (16 patients), the small bowel in 31% (13 patients) and the ileocaecal region in 31%. In small bowel disease, the indication for operation was either an intestinal obstruction or an internal abscess. In colonic locations, poor response to medical therapy was the indication for operation in 10 patients (63%), and an acute complication in the remaining cases. The operations performed were always "radical resections": 13 resections of small bowel, 13 ileocaecal resections, 7 ileocolectomies with ileosigmoidostomies, 6 ileocolectomies with ileorectostomies, 2 left side hemicolectomies with colorectostomies and one total coloproctectomy. There was no operative mortality. A post-operative complication occurred in two patients (4.8%). The recurrence rate was 12% after 30 months average follow up in the 34 patients with only one operation for Crohn's disease. There was no second recurrence in the 8 patients operated for a first recurrence. The factors affecting recurrence after resection were: a short pre-operative time interval since first clinical symptoms: 4.6 years versus 5.3 years without recurrence (p less than 0.01); the colonic location of the Crohn's disease (p less than 0.02). Colonic location rate of the disease was found to be higher in this study as compared to others. Since "radical resection" fails to cure all patients, surgery should be restricted to acute on chronic complications.

摘要

1983年至1987年间,42例患者因克罗恩病的急性或慢性并发症接受了手术切除。结肠受累的患者占38%(16例),小肠受累的患者占31%(13例),回盲部受累的患者占31%。在小肠疾病中,手术指征为肠梗阻或腹腔内脓肿。在结肠疾病中,10例患者(63%)的手术指征是对药物治疗反应不佳,其余病例为急性并发症。所进行的手术均为“根治性切除术”:13例小肠切除术、13例回盲部切除术、7例回结肠切除术加回肠乙状结肠吻合术、6例回结肠切除术加回肠直肠吻合术、2例左侧半结肠切除术加结肠直肠吻合术以及1例全结肠直肠切除术。无手术死亡病例。2例患者(4.8%)出现术后并发症。在仅接受过一次克罗恩病手术的34例患者中,平均随访30个月后的复发率为12%。8例因首次复发而接受手术的患者未出现二次复发。影响切除术后复发的因素有:自首次出现临床症状以来术前时间间隔较短:复发患者为4.6年,未复发患者为5.3年(p<0.01);克罗恩病位于结肠(p<0.02)。与其他研究相比,本研究中该病的结肠受累率更高。由于“根治性切除术”不能治愈所有患者,手术应仅限于急性或慢性并发症。

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