Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora University of Wisconsin Medical Group, Aurora Health Care, 3033 South 27th Street, Milwaukee, WI 53215, USA.
Clin Geriatr Med. 2012 Nov;28(4):555-73. doi: 10.1016/j.cger.2012.08.005.
Aging is associated with an increased prevalence of cardiac arrhythmias, which contribute to higher morbidity and mortality in the elderly. The frequency of cardiac arrhythmias, particularly atrial fibrillation and ventricular tachyarrhythmia, is projected to increase as the population ages, greatly impacting health care resource utilization. Several clinical factors associated with the risk of arrhythmias have been identified in the population, yet the molecular bases for the increased predisposition to arrhythmogenesis in the elderly are not fully understood. This review highlights the epidemiology of cardiac dysrhythmias, changes in cardiac structure and function associated with aging, and the basis for arrhythmogenesis in the elderly.
衰老是与心律失常的发生率增加相关的，这会导致老年人的发病率和死亡率更高。随着人口老龄化，心律失常的频率，特别是心房颤动和室性心动过速，预计会增加，这将极大地影响医疗保健资源的利用。在人群中已经确定了与心律失常风险相关的几个临床因素，但老年人对心律失常发生的易感性增加的分子基础尚不完全清楚。本综述强调了心脏心律失常的流行病学，与衰老相关的心脏结构和功能的变化，以及老年人心律失常发生的基础。
