与衰老相关的心血管变化及其与心力衰竭的关系。
Aging-associated cardiovascular changes and their relationship to heart failure.
机构信息
Human Cardiovascular Studies, Laboratory of Cardiovascular Science, Intramural Research Program, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, NM-500, 3001 South Hanover Street, Baltimore, MD 21225, USA.
出版信息
Heart Fail Clin. 2012 Jan;8(1):143-64. doi: 10.1016/j.hfc.2011.08.011.
Abstract
Aging represents a convergence of declining cardioprotective systems and increasing disease processes that is fertile ground for the development of heart failure. Fifty percent of all heart failure diagnoses and 90% of all heart failure deaths occur in individuals older than 70. This article discusses the microscopic and macroscopic changes in cardiovascular structure, function, protective systems, and disease associated with aging. In addition to outlining important clinical considerations and conditions in older persons, the link between normal aging and the elevated risk for development of stage B heart failure is explained and potential therapeutic pathways are highlighted.
摘要
衰老是心脏保护性系统下降和疾病进程增加的交汇点，为心力衰竭的发展提供了肥沃的土壤。50%的心力衰竭诊断和 90%的心力衰竭死亡发生在 70 岁以上的人群中。本文讨论了与衰老相关的心血管结构、功能、保护系统和疾病的微观和宏观变化。除了概述老年人的重要临床注意事项和情况外，还解释了正常衰老与心力衰竭 B 期发展风险增加之间的联系，并强调了潜在的治疗途径。
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本文引用的文献
1
Mechanisms of vascular aging: new perspectives.血管老化的机制：新视角。
J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1028-41. doi: 10.1093/gerona/glq113. Epub 2010 Jun 24.
2
Aging, telomeres and heart failure.衰老、端粒与心力衰竭。
Heart Fail Rev. 2010 Sep;15(5):479-86. doi: 10.1007/s10741-010-9173-7.
3
Cardiomyogenesis in the adult human heart.成人心脏中的心肌发生。
Circ Res. 2010 Jul 23;107(2):305-15. doi: 10.1161/CIRCRESAHA.110.223024. Epub 2010 Jun 3.
4
Central haemodynamics and clinical outcomes: going beyond brachial blood pressure?中心血流动力学与临床结局：超越肱动脉血压？
Eur Heart J. 2010 Aug;31(15):1819-22. doi: 10.1093/eurheartj/ehq125. Epub 2010 May 15.
5
The role of inflammatory and fibrogenic pathways in heart failure associated with aging.炎症和纤维生成途径在与衰老相关的心力衰竭中的作用。
Heart Fail Rev. 2010 Sep;15(5):415-22. doi: 10.1007/s10741-010-9161-y.
6
Involvement of NADPH oxidase in age-associated cardiac remodeling.NADPH 氧化酶在与年龄相关的心脏重构中的作用。
J Mol Cell Cardiol. 2010 Apr;48(4):765-72. doi: 10.1016/j.yjmcc.2010.01.006. Epub 2010 Jan 15.
7
Arterial aging: a journey into subclinical arterial disease.动脉老化：亚临床动脉疾病之旅。
Curr Opin Nephrol Hypertens. 2010 Mar;19(2):201-7. doi: 10.1097/MNH.0b013e3283361c0b.
8
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9
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10
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J Am Coll Cardiol. 2009 Oct 27;54(18):1730-4. doi: 10.1016/j.jacc.2009.05.070.
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