Liver Center of Excellence, Virginia Mason Medical Center, 1100 Ninth Avenue, Seattle, WA 98101, USA.
Clin Liver Dis. 2012 Nov;16(4):827-37. doi: 10.1016/j.cld.2012.08.010.
In addition to directly causing liver disease, alcohol consumption is a common comorbid condition with other chronic liver diseases and may exacerbate liver injury, particularly in nonalcoholic fatty liver disease, chronic viral hepatitis, hereditary hemochromatosis, and autoimmune liver diseases. This synergism can result in increased hepatic inflammation and accelerated rates of fibrosis, with more rapid and earlier development of cirrhosis, and also increase the risk for liver cancer and death from liver disease.
除了直接导致肝脏疾病外，饮酒还是其他慢性肝病的常见合并症，可能会加重肝损伤，尤其是在非酒精性脂肪性肝病、慢性病毒性肝炎、遗传性血色素沉着症和自身免疫性肝病中。这种协同作用会导致肝脏炎症增加和纤维化速度加快，肝硬化更早更快地发展，还会增加肝癌和死于肝病的风险。
