肝癌与酒精。

Liver cancer and alcohol.

机构信息

Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

出版信息

Clin Liver Dis. 2012 Nov;16(4):839-50. doi: 10.1016/j.cld.2012.08.011.

DOI:10.1016/j.cld.2012.08.011

PMID:23101985

Abstract

Annually, hepatocellular carcinoma is diagnosed in approximately a half-million people worldwide. Based on the association of alcohol with cancer, a International Agency for Research on Cancer working group recently deemed alcoholic beverages "carcinogenic to humans," causally related to occurrence of malignant tumors of the oral cavity, pharynx, larynx, esophagus, liver, colorectum, and female breast. Alcohol metabolism in the liver leads to reactive oxygen species production, induction of activity of cytochrome P450s, and reduction of antioxidants. This review analyzes the epidemiology and pathogenesis of alcohol in hepatocellular cancer.

摘要

每年，全球约有 50 万人被诊断出患有肝细胞癌。鉴于酒精与癌症之间的关联，国际癌症研究机构的一个工作组最近将酒精饮料认定为“对人类致癌”，因果关系涉及口腔、咽、喉、食管、肝、结肠直肠和女性乳房恶性肿瘤的发生。酒精在肝脏中的代谢会导致活性氧的产生、细胞色素 P450 活性的诱导和抗氧化剂的减少。本综述分析了酒精在肝细胞癌中的流行病学和发病机制。