14,15-环氧二十碳三烯酸促进人单核细胞肿瘤U937细胞的内皮细胞依赖性黏附。
14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells.
作者信息
Pritchard K A, Tota R R, Stemerman M B, Wong P Y
机构信息
Department of Physiology, New York Medical College, Valhalla 10595.
出版信息
Biochem Biophys Res Commun. 1990 Feb 28;167(1):137-42. doi: 10.1016/0006-291x(90)91741-a.
Arachidonic acid (AA) can be metabolized in endothelial cells (EC) to a series of epoxides via cytochrome P-450 epoxygenase with 14,15 epoxyeicosatrienoic acid (14,15-EET) as the major product. In this communication we report that 14,15-EET significantly enhances U937 cell attachment to EC with maximal cell attachment at 2.5 to 5 x 10(-7) M 14,15-EET. Thus, 14,15-EET may play a substantial role in inflammation and/or atherogenesis by inducing monocyte attachment to EC.
花生四烯酸（AA）在内皮细胞（EC）中可通过细胞色素P-450环氧酶代谢为一系列环氧化物，其中14,15-环氧二十碳三烯酸（14,15-EET）为主要产物。在本通讯中，我们报告14,15-EET能显著增强U937细胞与内皮细胞的黏附，在2.5至5×10⁻⁷ M的14,15-EET浓度下细胞黏附达到最大值。因此，14,15-EET可能通过诱导单核细胞与内皮细胞的黏附在炎症和/或动脉粥样硬化形成中发挥重要作用。
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