Li Weixing, Wu Han, Song Chao
Laboratory Medicine, Zhejiang Provincial People's Hospital, Zhejiang, China,
Tumour Biol. 2013 Oct;34(5):2675-81. doi: 10.1007/s13277-013-0818-8. Epub 2013 May 8.
Many studies have reported the role of transforming growth factor-β1 (TGF-β1) -509C/T or +869T/C polymorphism with hepatocellular carcinoma (HCC) risk. However, these studies have yielded conflicting results. Hence, we performed this meta-analysis to investigate the association between TGF-β1 -509C/T or +869T/C polymorphism and HCC. A total of 11 studies including 2,577 HCC cases and 4,107 controls were included in the meta-analysis. Overall, TGF-β1 -509C/T (or +869T/C) polymorphism was not associated with HCC risk (homogeneous co-dominant model: OR = 1.29, 95 % CI = 0.88-1.89; heterogeneous co-dominant model: OR = 1.15, 95 % CI = 0.91-1.45; dominant model: OR = 1.14, 95 % CI = 0.87-1.48; recessive model: OR = 1.15, 95 % CI = 0.89-1.49). In the subgroup analysis, TGF-β1 -509C/T (or +869T/C) polymorphism was significantly associated with HCC risk in Caucasians under the recessive model (OR = 1.65, 95 % CI = 1.07-2.55) but not in other genetic models. In addition, we did not observe significant association in Asians under all genetic models. In conclusion, our meta-analysis indicates that TGF-β1 -509C/T (or +869T/C) polymorphism was not associated with risk of HCC, although a marginal association was found for Caucasians. However, a study with the larger sample size is needed to further evaluate gene-environment interaction on the association.
许多研究报告了转化生长因子-β1（TGF-β1）-509C/T或+869T/C多态性与肝细胞癌（HCC）风险的关系。然而，这些研究结果相互矛盾。因此，我们进行了这项荟萃分析，以研究TGF-β1 -509C/T或+869T/C多态性与HCC之间的关联。荟萃分析共纳入11项研究，包括2577例HCC病例和4107例对照。总体而言，TGF-β1 -509C/T（或+869T/C）多态性与HCC风险无关（同质共显性模型：OR = 1.29，95%CI = 0.88 - 1.89；异质共显性模型：OR = 1.15，95%CI = 0.91 - 1.45；显性模型：OR = 1.14，95%CI = 0.87 - 1.48；隐性模型：OR = 1.15，95%CI = 0.89 - 1.49）。在亚组分析中，TGF-β1 -509C/T（或+869T/C）多态性在隐性模型下与白种人的HCC风险显著相关（OR = 1.65，95%CI = 1.07 - 2.55），但在其他遗传模型中无此关联。此外，在所有遗传模型下，我们在亚洲人中均未观察到显著关联。总之，我们的荟萃分析表明，TGF-β1 -509C/T（或+869T/C）多态性与HCC风险无关，尽管在白种人中发现了微弱关联。然而，需要更大样本量的研究来进一步评估基因-环境相互作用对该关联的影响。
