Nasrin S, Bachar S C, Choudhuri M S K
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):170-4. doi: 10.4314/ajtcam.v8i5S.22. Epub 2011 Jul 3.
Chondrokola Rosh (CKR) is a traditional metallic Ayurvedic preparation widely used by the rural and ethnic people of Bangladesh in dysuria. It is a preparation of various roasted metals (Hg and Cu), non-metal (sulphur and Mica) and medicinal herbs. Considering the controversy over the risk of toxic heavy metals in Ayurvedic herbo-mineral preparations, toxicological parameters on liver functions were investigated. A single dose of 100mg/kg body weight of the preparation was administered orally to the rats of both sexes for ninety days. In this evaluation a statistically significant (p<0.001) increase of serum albumin levels in male (17%) and female (15%) rat groups were observed. On the other hand, the plasma bilirubin level was decreased 50% and 28% respectively in both rats groups. But no remarkable differences were observed in plasma protein, sGPT, sGOT and ALP activities from their corresponding control values. This study showed that CKR had no remarkable toxic effect on liver of the animals despite the presence of traces of transformed heavy metals.
软骨科拉罗什（CKR）是一种传统的阿育吠陀金属制剂，孟加拉国农村和少数民族广泛用于治疗排尿困难。它是由各种焙烧金属（汞和铜）、非金属（硫和云母）和草药制成的制剂。考虑到阿育吠陀草药-矿物质制剂中有毒重金属风险的争议，对肝功能的毒理学参数进行了研究。以100mg/kg体重的单剂量将该制剂口服给予雌雄大鼠90天。在该评估中，观察到雄性（17%）和雌性（15%）大鼠组血清白蛋白水平有统计学意义的显著升高（p<0.001）。另一方面，两组大鼠的血浆胆红素水平分别降低了50%和28%。但血浆蛋白、sGPT、sGOT和ALP活性与相应对照值相比无显著差异。该研究表明，尽管存在微量转化重金属，CKR对动物肝脏没有显著毒性作用。
