Sarkar Prasanta Kumar, Das Mukhopadhyay Chitrangada
Department of Rasashastra, J. B. Roy State Ayurvedic Medical College and Hospital West Bengal University of Health Sciences, Kolkata, 700004 West Bengal India.
Centre for Healthcare Science and Technology, Indian Institute of Engineering Science Technology, Shibpur, Howrah, 711103 West Bengal India.
Int Nano Lett. 2021;11(3):197-203. doi: 10.1007/s40089-020-00323-9. Epub 2021 Jan 6.
The pandemic COVID-19 has affected more than seventy million people globally. The whole world is eagerly waiting for an effective antiviral therapy to combat COVID-19, but it is yet to get. The emergence of COVID-19 makes imperative the need for safe and potent antiviral drugs. Many metal nanoparticles exhibit significant antiviral potential against many viral diseases. The Ayurvedic system of medicine is the treasure of many metal nanoparticulate drugs termed as Bhasma.
Gold, silver, copper, zinc and iron oxide nanoparticles are effective against coronavirus. A possible mechanism of action of the metal nanoparticles against coronavirus is a disruption of outer layers of coronavirus. Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma are recommended for COVID-19 treatment due to the ability to reduce the plasma interleukins, interferons and TNFα levels.
The Ayurvedic Bhasma preparations are unique metal nanoparticles. These metal nanoparticles are safe, stable in solid state and are having excellent biological activities. Ayurvedic metal nanoparticles, Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma could be proved as novel antiviral agents against SARS-CoV-2 for their anti-inflammatory, immunomodulatory, antiviral and adjuvant activities.
新冠疫情已在全球影响了超过7000万人。全世界都在急切等待一种有效的抗病毒疗法来对抗新冠病毒，但尚未得到。新冠病毒的出现使得对安全且有效的抗病毒药物的需求变得迫切。许多金属纳米颗粒对多种病毒性疾病展现出显著的抗病毒潜力。阿育吠陀医学体系是许多被称为“Bhasma”的金属纳米颗粒药物的宝库。
金、银、铜、锌和氧化铁纳米颗粒对冠状病毒有效。金属纳米颗粒对抗冠状病毒的一种可能作用机制是破坏冠状病毒的外层。由于能够降低血浆白细胞介素、干扰素和肿瘤坏死因子α水平，推荐使用Swarna Bhasma、Rajata Bhasma、Tamra Bhasma和Yashada Bhasma来治疗新冠病毒。
阿育吠陀Bhasma制剂是独特的金属纳米颗粒。这些金属纳米颗粒安全，固态稳定，且具有出色的生物活性。阿育吠陀金属纳米颗粒Swarna Bhasma、Rajata Bhasma、Tamra Bhasma和Yashada Bhasma因其抗炎、免疫调节、抗病毒和佐剂活性，可能被证明是对抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的新型抗病毒剂。
