预处理的女性乳腺癌患者癌胚抗原与癌抗原15.3的相关性研究
Correlation study of Carcino Embryonic Antigen & Cancer Antigen 15.3 in pretreated female breast cancer patients.
作者信息
Thriveni K, Krishnamoorthy Lakshmi, Ramaswamy Girija
机构信息
Department of Biochemistry, Kidwai Memorial Institute of Oncology, Hosur Road, 560 029 Bangalore, Karnataka.
出版信息
Indian J Clin Biochem. 2007 Mar;22(1):57-60. doi: 10.1007/BF02912882.
Carcino Embryonic Antigen (CEA) and Cancer Antigen 15.3 (CA15.3) are the most common tumor markers in breast cancer patients. Measurement of circulating tumor markers is a non-invasive quantitative method. Serum levels of CEA and CA 15.3 were studied in female breast cancer patients prior to treatment. To evaluate the utility of these markers, 207 Breast carcinoma patients belonging to all the stages were considered. Healthy age matched 75 female individuals formed the control group. The serum levels of CEA and CA 15.3 were analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Results were taken and compared with stages, tumor size, node and grade. The serum CA 15.3 levels were significant in all the study parameters whereas serum CEA levels showed no significant changes with any of the parameters. Measurement of serum CA 15.3 levels showed significant correlation (24.8%) with advanced stages and larger tumor sizes, whereas serum CEA levels did not show any significant correlation in breast cancer patients prior to treatment.
癌胚抗原（CEA）和癌抗原15.3（CA15.3）是乳腺癌患者中最常见的肿瘤标志物。循环肿瘤标志物的检测是一种非侵入性定量方法。在女性乳腺癌患者治疗前对其血清CEA和CA15.3水平进行了研究。为评估这些标志物的效用，纳入了207例处于所有分期的乳腺癌患者。75名年龄匹配的健康女性个体组成对照组。采用酶联免疫吸附测定（ELISA）法分析血清CEA和CA15.3水平。记录结果并与分期、肿瘤大小、淋巴结及分级进行比较。血清CA15.3水平在所有研究参数中均有显著意义，而血清CEA水平在任何参数中均未显示出显著变化。血清CA15.3水平的检测显示与晚期和较大肿瘤大小存在显著相关性（24.8%），而血清CEA水平在治疗前的乳腺癌患者中未显示出任何显著相关性。
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