厄贝沙坦对链脲佐菌素诱导的糖尿病肾病的影响：一项干预性研究。
Effect of irbesartan on streptozotocin induced diabetic nephropathy: An interventionary study.
作者信息
Vaishya Richa, Singh Janardhan, Lal Harbans
机构信息
Department of Biochemistry, Pt. B.D Sharma PGIMS, Rohtak, Haryana India.
出版信息
Indian J Clin Biochem. 2008 Apr;23(2):195-7. doi: 10.1007/s12291-008-0043-1. Epub 2008 Jun 11.
Abstract
Effect of irbesartan, an angiotensin II receptor antagonist, was studied in streptozotocin (STZ) induced diabetic nephropathy. Polyuria, proteinuria, blood urea, creatinine clearance, and urinary electrolytes were determined to assess kidney damage. There was a significant increase in urine volume, urinary protein and blood urea in STZ induced diabetic rats. On the other hand, irbesartan treatment resulted in a significant reduction in urinary protein and blood urea in these rats. Irbesartan treatment also improved creatinine clearance and exhibited a natriuretic effect in these animals. Results suggest that irbesartan treatment ameliorate STZ induced diabetic nephropathic changes, in rats.
摘要
研究了血管紧张素II受体拮抗剂厄贝沙坦对链脲佐菌素（STZ）诱导的糖尿病肾病的影响。通过测定多尿、蛋白尿、血尿素、肌酐清除率和尿电解质来评估肾脏损伤。STZ诱导的糖尿病大鼠尿量、尿蛋白和血尿素显著增加。另一方面，厄贝沙坦治疗使这些大鼠的尿蛋白和血尿素显著降低。厄贝沙坦治疗还改善了肌酐清除率，并在这些动物中表现出利钠作用。结果表明，厄贝沙坦治疗可改善大鼠STZ诱导的糖尿病肾病变化。
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本文引用的文献
1
AUTOMATED AND MANUAL DIRECT METHODS FOR THE DETERMINATION OF BLOOD UREA.测定血尿素的自动化和手工直接法
Clin Chem. 1965 Jun;11:624-7.
2
Prevention of end-stage renal disease due to type 2 diabetes.2型糖尿病所致终末期肾病的预防
N Engl J Med. 2001 Sep 20;345(12):910-2. doi: 10.1056/NEJM200109203451209.
3
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes.厄贝沙坦对2型糖尿病患者糖尿病肾病发展的影响。
N Engl J Med. 2001 Sep 20;345(12):870-8. doi: 10.1056/NEJMoa011489.
4
A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function.饮食蛋白质限制对肾功能下降速率影响的荟萃分析。
Am J Kidney Dis. 1998 Jun;31(6):954-61. doi: 10.1053/ajkd.1998.v31.pm9631839.
5
Benefits of long-term antihypertensive treatment on prognosis in diabetic nephropathy.长期抗高血压治疗对糖尿病肾病预后的益处。
Kidney Int. 1996 Jun;49(6):1778-82. doi: 10.1038/ki.1996.266.
6
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.血管紧张素转换酶抑制对糖尿病肾病的影响。协作研究组。
N Engl J Med. 1993 Nov 11;329(20):1456-62. doi: 10.1056/NEJM199311113292004.
7
Hypercholesterolemia--a determinant of renal function loss and deaths in IDDM patients with nephropathy.
Kidney Int Suppl. 1994 Feb;45:S125-31.
8
The rising tide of endstage renal failure from diabetic nephropathy type II--an epidemiological analysis.
Nephrol Dial Transplant. 1995;10(4):462-7. doi: 10.1093/ndt/10.4.462.
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