Department of Internal Medicine, Hanyang University College of Medicine, Guri, Gyeonggi-do, Korea.
J Neurogastroenterol Motil. 2012 Oct;18(4):412-8. doi: 10.5056/jnm.2012.18.4.412. Epub 2012 Oct 9.
BACKGROUND/AIMS: Gastric stasis in migraineurs remains controversial. The aim of this study is to investigate gastric emptying (GE) time, and any associations between GE parameters and dyspeptic symptoms among patients with functional dyspepsia (FD) and migraine without any gastrointestinal symptoms during the interictal period.
We enrolled 27 migraine patients, 32 FD patients and 12 healthy people as controls, and performed GE scintigraphy as gastric function test. Gastrointestinal symptoms were evaluated in the FD and migraine.
The age-adjusted mean gastric half-emptying time in FD (125.51 ± 52.55 minutes) patients was longer than in migraineurs (100.82 ± 23.94 minutes, P = 0.035) and controls (95.25 ± 23.29 minutes, P = 0.021). The percentage of gastric retention was higher in FD than in migraine. However, migraineurs did not show an obvious delayed gastric emptying or an increase of gastric retention when compared to the normal controls. The association between each dyspeptic symptom and GE parameters was not significant, but postprandial fullness and early satiety showed a tendency of delayed GE. In migraineurs, GE time did not show significant association with nausea and vomiting during interictal periods.
Delayed GE does not appear to be a mechanism that patients with FD and migraine have in common. Migraineurs without dyspepsia during interictal period had normal GE, and further study for association with FD should be investigated.
背景/目的：偏头痛患者存在胃动力障碍仍存在争议。本研究旨在探讨功能性消化不良（FD）患者和间歇期无任何胃肠道症状的偏头痛患者的胃排空（GE）时间，以及 GE 参数与消化不良症状之间的任何关联。
我们招募了 27 名偏头痛患者、32 名 FD 患者和 12 名健康人作为对照组，并进行了 GE 闪烁显像作为胃功能测试。在 FD 和偏头痛患者中评估了胃肠道症状。
FD（125.51 ± 52.55 分钟）患者的年龄调整后胃半排空时间长于偏头痛患者（100.82 ± 23.94 分钟，P = 0.035）和对照组（95.25 ± 23.29 分钟，P = 0.021）。FD 患者的胃潴留率高于偏头痛患者。然而，与正常对照组相比，偏头痛患者并未表现出明显的胃排空延迟或胃潴留增加。每个消化不良症状与 GE 参数之间没有显著关联，但餐后饱胀和早饱表现出 GE 延迟的趋势。在偏头痛患者中，GE 时间与间歇期恶心和呕吐之间无明显关联。
胃动力障碍似乎不是 FD 和偏头痛患者共有的机制。间歇期无消化不良的偏头痛患者具有正常的 GE，应进一步研究与 FD 的关联。
