Aurora Sheena, Kori Shashidhar, Barrodale Patricia, Nelsen Andrew, McDonald Susan
Swedish Neuroscience Institute - Swedish Headache Center, Seattle, WA 98104, USA.
Headache. 2007 Nov-Dec;47(10):1443-6. doi: 10.1111/j.1526-4610.2007.00922.x. Epub 2007 Sep 12.
To evaluate and compare gastric motility and emptying during spontaneous migraine to previous observations from induced migraine.
We have previously demonstrated a delay in gastric emptying both during the interictal period and during an induced migraine. A limitation noted in these studies was whether there are differences gastrointestinally during a visually induced migraine compared to spontaneous migraines. To address this, 9 additional studies have been performed to ascertain if there is a similar delay during spontaneous migraine
Gastric scintigraphy using a standard meal was performed in 3 subjects during 3 periods: spontaneous migraine, induced migraine, and interictal period.
On average, the time to half emptying was delayed during spontaneous migraine (124 minutes), during induced migraine (182 minutes), and during the interictal period migraine (243 minutes) compared to normative values established at our center (112 minutes). On average, similar gastric slowing was seen in all 3 groups when the percentage of nuclear material remaining in the stomach at 2 hours was measured.
This study provides additional evidence of gastric stasis in migraineurs interictally during induced and spontaneous migraine.
评估并比较自发性偏头痛期间的胃动力和排空情况与之前诱导性偏头痛的观察结果。
我们之前已经证明在发作间期和诱导性偏头痛期间胃排空均延迟。这些研究中指出的一个局限性是，与自发性偏头痛相比，视觉诱导性偏头痛期间胃肠道是否存在差异。为解决这一问题，又进行了9项研究，以确定自发性偏头痛期间是否存在类似的延迟。
对3名受试者在3个时间段进行标准餐胃闪烁扫描：自发性偏头痛、诱导性偏头痛和发作间期。
与我们中心确定的标准值（112分钟）相比，自发性偏头痛期间（124分钟）、诱导性偏头痛期间（182分钟）和发作间期偏头痛期间（243分钟），平均排空至一半的时间均延迟。当测量2小时时胃内剩余核物质的百分比时，平均而言，所有3组均出现了类似的胃动力减慢。
本研究为偏头痛患者在诱导性和自发性偏头痛发作间期出现胃潴留提供了更多证据。
