Redington A N, Rigby M L, Shinebourne E A, Oldershaw P J
Cardiac Department, Brompton Hospital, London.
Br Heart J. 1990 Jan;63(1):45-9. doi: 10.1136/hrt.63.1.45.
Ventricular pressure-volume diagrams were obtained from the right ventricle in patients before and after relief of right ventricular pressure load, in patients with volume loaded right ventricles, and from the left ventricle in patients after the Mustard procedure for transposition of the great arteries. The patterns of ejection during pressure development and decline were similar in patients after relief of pressure load and in those with isolated volume load. A right ventricular pressure load, however, reduced ejection during the two "isovolumic" periods, and the overall shape of the pressure-volume loop resembled that of the normal left ventricle. Pressure-volume diagrams obtained from the left ventricle after the Mustard procedure were indistinguishable from the normal right ventricle, which accords with the hypothesis that the normal right ventricular contraction pattern is a consequence of loading conditions rather than a reflection of an intrinsic property of the myocardium.
在右心室压力负荷解除前后的患者、容量负荷性右心室患者以及大动脉转位行Mustard手术后患者的左心室中获取心室压力-容积图。压力负荷解除后的患者与单纯容量负荷患者在压力上升和下降过程中的射血模式相似。然而,右心室压力负荷在两个“等容”期减少了射血,并且压力-容积环的整体形状类似于正常左心室。Mustard手术后从左心室获得的压力-容积图与正常右心室无法区分,这与正常右心室收缩模式是负荷条件的结果而非心肌内在特性反映的假设相符。