来自内生真菌链格孢菌的两种新化合物。

Two new compounds from an endophytic fungus Alternaria solani.

作者信息

Ai Hong-Lian, Zhang Li-Mei, Chen Yan-Ping, Zi Shu-Hui, Xiang Hong, Zhao Da-Ke, Shen Yong

机构信息

School of Agriculture and Biological Technic, Yunnan Agricultural University, Kunming 650201, China.

出版信息

J Asian Nat Prod Res. 2012;14(12):1144-8. doi: 10.1080/10286020.2012.733701. Epub 2012 Oct 29.

DOI:10.1080/10286020.2012.733701

PMID:23106531

Abstract

Two new secondary metabolites, named 7-dehydroxyl-zinniol (1) and 20-hydroxyl-ergosta-4,6,8(14),22-tetraen-3-one (2), were isolated from the culture of Alternaria solani, an endophytic fungal strain residing in the roots of Aconitum transsectum. Their structures were elucidated on the basis of comprehensive spectroscopic analyses including IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR. Biological activity tests indicated that compound 1 showed moderate anti-HBV activity.

摘要

从横断乌头根部内生真菌链格孢菌（Alternaria solani）的培养物中分离出两种新的次生代谢产物，分别命名为7-脱羟基百日菊醇（1）和20-羟基-麦角甾-4,6,8(14),22-四烯-3-酮（2）。通过包括红外光谱（IR）、电喷雾电离质谱（ESI-MS）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D和2D NMR）在内的综合光谱分析确定了它们的结构。生物活性测试表明，化合物1具有中等抗乙肝病毒（HBV）活性。