Wu Wen-Bin, Yue Gao-Chao, Huang Qi-Lin, Sun Ling-Ling, Zhang Wen
a School of Life Science, East China Normal University , Shanghai 200241 , China.
J Asian Nat Prod Res. 2014;16(7):777-82. doi: 10.1080/10286020.2014.896343. Epub 2014 Mar 19.
A new secondary metabolite, named altertoxin IV (1), together with altertoxin II (2), was isolated from the fermentation broth of Alternaria tenuissima, an endophytic fungal strain residing in the stem of Tribulus terrestris L. The structure of new compound 1 was established by HR-ESI-MS, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. In their in vitro bioassay, compound 2 exhibited moderate cytotoxic activity against PC-3 cell lines with an IC50 value of 14.28 μM.
从生长于刺蒺藜茎部的内生真菌细极链格孢（Alternaria tenuissima）的发酵液中，分离出一种名为变应毒素IV（1）的新次级代谢产物，以及变应毒素II（2）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、多核核磁共振光谱和单晶X射线衍射法确定了新化合物1的结构。在体外生物活性测试中，化合物2对PC-3细胞系表现出中等细胞毒性活性，IC50值为14.28 μM。
