Wang Xiao-Zheng, Luo Xiao-Hong, Xiao Jie, Zhai Ming-Ming, Yuan Yun, Zhu Ying, Crews Phillip, Yuan Cheng-Shan, Wu Quan-Xiang
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, PR China; State Key Laboratory of Grassland Agro-Ecosystems, Lanzhou University, Lanzhou 730000, PR China.
Fitoterapia. 2014 Dec;99:184-90. doi: 10.1016/j.fitote.2014.09.017. Epub 2014 Oct 2.
Three new pyrones, solanapyrones P-R (1-3), were afforded by the extracts of the endophytic fungus Alternaria tenuissima SP-07 isolated from the fresh root of Chinese herbal medicine Salvia przewalskii, along with the known solanapyrones (4-6) and benzopyrones (7-9). Solanapyrones P (1) and Q (2) possess an unprecedented nor-solanapyrone skeleton as natural products. Their structures were determined on the basis of NMR and HR-ESI-MS analysis. The plausible biosynthetic pathways to those unknown compounds were discussed. All the isolated compounds were evaluated for their antibacterial activities against six bacteria.
从中药材甘肃丹参新鲜根部分离得到的内生真菌细极链格孢菌SP-07的提取物中，获得了三种新的吡喃酮类化合物，即茄链格孢菌素P - R（1 - 3），同时还得到了已知的茄链格孢菌素（4 - 6）和苯并吡喃酮类化合物（7 - 9）。茄链格孢菌素P（1）和Q（2）具有前所未有的天然产物去甲茄链格孢菌素骨架。它们的结构通过核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESI-MS）分析得以确定。文中还讨论了这些未知化合物可能的生物合成途径。对所有分离得到的化合物进行了针对六种细菌的抗菌活性评估。
