Altunay Ilknur, Kucukunal Asli, Sarikaya Sezgi, Tukenmez Demirci Gulsen
Department of Dermatology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Int Wound J. 2014 Aug;11(4):350-3. doi: 10.1111/j.1742-481X.2012.01102.x. Epub 2012 Oct 29.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterised with ulcerations. Inflammatory bowel diseases (ulcerative colitis and Crohn's disease) and haematologic diseases (leukaemia, preleukaemia and monoclonal gammopathy) have been reported in about 40-50% of PG patients in whom the treatment of the underlying disease is important for the improvement of the lesions. We herein report a colorectal adenocarcinoma patient with PG, who responded partially to topical treatments and systemic immunosuppressants and healed completely with the aid of surgical wound repair and hyperbaric oxygen therapy.
坏疽性脓皮病（PG）是一种以溃疡为特征的嗜中性皮病。约40%-50%的PG患者伴有炎症性肠病（溃疡性结肠炎和克罗恩病）和血液系统疾病（白血病、白血病前期和单克隆丙种球蛋白病），对这些基础疾病的治疗对于改善皮损很重要。我们在此报告1例患有PG的结肠直肠癌患者，该患者对局部治疗和全身免疫抑制剂部分有效，并在手术伤口修复和高压氧治疗的帮助下完全愈合。
