Department of Neurology, MS Center and Laboratory of Neuroimmunology, Agnes-Ginges Center for Neurogenetics, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
J Neurol Sci. 2013 Jan 15;324(1-2):1-9. doi: 10.1016/j.jns.2012.09.031. Epub 2012 Oct 27.
To overcome the limited capacity of the CNS for regeneration, the theoretical alternative would be to use stem cells for more effective management of chronic degenerative and inflammatory neurological conditions, and also of acute neuronal damage from injuries or cerebrovascular diseases. Although the adult brain contains small numbers of stem cells in restricted areas, this intrinsic stem cell repertoire is small and does not measurably contribute to functional recovery. Embryonic cells carrying pluripotent and self-renewal properties represent the stem cell prototype, but there are additional somatic stem cells that may be harvested and expanded from various tissues during adult life. Stem cell transplantation is based on the assumption that such cells may have the potential to regenerate or support the survival of the existing, partially damaged cells. This review summarizes the state-of-the-art and the clinical worldwide experience with the use of various types of stem cells in neurological diseases.
为了克服中枢神经系统再生能力有限的问题，理论上的另一种选择是使用干细胞来更有效地治疗慢性退行性和炎症性神经疾病，以及治疗因损伤或脑血管疾病导致的急性神经元损伤。尽管成年大脑在有限的区域中含有少量的干细胞，但这种内在的干细胞库很小，对功能恢复没有明显贡献。携带多能性和自我更新特性的胚胎细胞代表了干细胞原型，但还有其他的成体干细胞，可以在成年期从各种组织中采集和扩增。干细胞移植的假设是，这些细胞可能具有再生或支持现有部分受损细胞存活的潜力。这篇综述总结了在神经疾病中使用各种类型的干细胞的最新技术和全球临床经验。
