自闭症的干细胞疗法：最新见解
Stem cell therapy in autism: recent insights.
作者信息
Siniscalco Dario, Kannan Suresh, Semprún-Hernández Neomar, Eshraghi Adrien A, Brigida Anna Lisa, Antonucci Nicola
机构信息
Department of Experimental Medicine, University of Campania, Napoli, Italy,
Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
出版信息
Stem Cells Cloning. 2018 Oct 23;11:55-67. doi: 10.2147/SCCAA.S155410. eCollection 2018.
Abstract
Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.
摘要
自闭症谱系障碍（ASD）具有核心特征：社交沟通和互动持续存在缺陷；行为、兴趣或活动存在局限的、重复的模式。ASD包含具有明确炎症状况和免疫系统功能障碍的异质性和复杂性神经发育病理。由于ASD发展背后的神经生物学变化，基于细胞的疗法已被提出并应用于ASD。事实上，干细胞具有特定的免疫特性，这使其成为ASD治疗中有前景的候选者。这篇全面的最新综述聚焦于ASD的细胞/分子异常、可能有用的干细胞类型、动物模型以及目前使用干细胞治疗自闭症的临床试验。同时也讨论了局限性。
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