Koszewicz Magdalena, Mendak Magdalena, Konopka Tomasz, Koziorowska-Gawron Ewa, Budrewicz Sławomir
Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.
J Orofac Pain. 2012 Fall;26(4):315-20.
To conduct a clinical electrophysiologic evaluation of autonomic nervous system functions in patients with burning mouth syndrome and Parkinson disease and estimate the type and intensity of the autonomic dysfunction.
The study involved 83 subjects-33 with burning mouth syndrome, 20 with Parkinson disease, and 30 controls. The BMS group included 27 women and 6 men (median age, 60.0 years), and the Parkinson disease group included 15 women and 5 men (median age, 66.5 years). In the control group, there were 20 women and 10 men (median age, 59.0 years). All patients were subjected to autonomic nervous system testing. In addition to the Low autonomic disorder questionnaire, heart rate variability (HRV), deep breathing (exhalation/inspiration [E/I] ratio), and sympathetic skin response (SSR) tests were performed in all cases. Parametric and nonparametric tests (ANOVA, Kruskal-Wallis, and Scheffe tests) were used in the statistical analysis.
The mean values for HRV and E/I ratios were significantly lower in the burning mouth syndrome and Parkinson disease groups. Significant prolongation of SSR latency in the foot was revealed in both burning mouth syndrome and Parkinson disease patients, and lowering of the SSR amplitude occurred in only the Parkinson disease group. The autonomic questionnaire score was significantly higher in burning mouth syndrome and Parkinson disease patients than in the control subjects, with the Parkinson disease group having the highest scores.
In patients with burning mouth syndrome, a significant impairment of both the sympathetic and parasympathetic nervous systems was found but sympathetic/parasympathetic balance was preserved. The incidence and intensity of autonomic nervous system dysfunction was similar in patients with burning mouth syndrome and Parkinson disease, which may suggest some similarity in their pathogeneses.
对灼口综合征和帕金森病患者的自主神经系统功能进行临床电生理评估，并评估自主神经功能障碍的类型和强度。
该研究纳入了83名受试者，其中33名患有灼口综合征，20名患有帕金森病，30名作为对照。灼口综合征组包括27名女性和6名男性（中位年龄60.0岁），帕金森病组包括15名女性和5名男性（中位年龄66.5岁）。对照组有20名女性和10名男性（中位年龄59.0岁）。所有患者均接受自主神经系统检测。除了低自主神经功能障碍问卷外，所有病例均进行了心率变异性（HRV）、深呼吸（呼气/吸气[E/I]比值）和交感皮肤反应（SSR）测试。统计分析采用参数和非参数检验（方差分析、Kruskal-Wallis检验和Scheffe检验）。
灼口综合征组和帕金森病组的HRV和E/I比值的平均值显著较低。灼口综合征和帕金森病患者均出现足部SSR潜伏期显著延长，而SSR波幅降低仅出现在帕金森病组。灼口综合征和帕金森病患者的自主神经问卷评分显著高于对照组，其中帕金森病组评分最高。
在灼口综合征患者中，发现交感神经和副交感神经系统均有明显损害，但交感/副交感神经平衡得以保留。灼口综合征和帕金森病患者自主神经系统功能障碍的发生率和强度相似，这可能提示它们在发病机制上存在一些相似之处。
