Jeong Haein, Choi Su-Hyun, Ha Na-Yeon, Ko Seok-Jae, Park Jae-Woo, Kim Jinsung
Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea.
Department of Digestive Diseases, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Medicine (Baltimore). 2024 Nov 22;103(47):e40670. doi: 10.1097/MD.0000000000040670.
This study aimed to identify the clinical characteristics of patients with burning mouth syndrome (BMS) according to the low frequency/high frequency (LF/HF) ratio in the heart rate variability test and to evaluate the potential of the LF/HF ratio as an indicator for the diagnostic or predictive assessment of patients with BMS. A total of 469 patients with BMS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital between January 1, 2018, and December 31, 2022, were included in the study. The patients were asked to rate their tongue pain on a visual analog scale before and after treatment. Heart rate variability testing and measurement of the unstimulated and stimulated salivary flow rates were conducted. The patients were divided into 3 groups according to their LF/HF ratios. Clinical characteristics, including tongue pain, salivary secretion, and concomitant symptoms, were compared between the groups. Spearman correlation analysis was performed to determine any significant correlation between the LF/HF ratio and the clinical symptoms. The patients were also classified into 2 groups according to psychological factors to analyze their effects on the clinical characteristics of BMS. The pretreatment pain score (PRPS), posttreatment pain score (POPS), and incidence rate of dry mouth symptoms were higher in the parasympathetically activated group than in the other groups. Spearman correlation analysis revealed a negative correlation between the LF/HF ratio and the PRPS. The PRPS and POPS were higher and the unstimulated salivary flow rate, stimulated salivary flow rate, and LF/HF ratio were lower in the group with psychological factors than in the group without psychological factors. The parasympathetic group reported higher PRPS and POPS and a higher incidence of dry mouth symptoms. This may be attributable to the role of psychological factors in BMS, which is a functional pain disorder. The different clinical characteristics based on the LF/HF ratio indicate that the LF/HF ratio may serve as a significant indicator for diagnosing or predicting the prognosis of patients with BMS.
本研究旨在根据心率变异性测试中的低频/高频（LF/HF）比值，确定灼口综合征（BMS）患者的临床特征，并评估LF/HF比值作为BMS患者诊断或预测评估指标的潜力。2018年1月1日至2022年12月31日期间，共有469名到庆熙大学韩医医院口腔疾病诊所就诊的BMS患者纳入本研究。要求患者在治疗前后用视觉模拟量表对舌部疼痛进行评分。进行心率变异性测试以及未刺激和刺激唾液流速的测量。根据LF/HF比值将患者分为3组。比较各组之间的临床特征，包括舌痛、唾液分泌和伴随症状。进行Spearman相关性分析，以确定LF/HF比值与临床症状之间是否存在显著相关性。还根据心理因素将患者分为2组，以分析其对BMS临床特征的影响。副交感神经激活组的治疗前疼痛评分（PRPS）、治疗后疼痛评分（POPS）和口干症状发生率高于其他组。Spearman相关性分析显示LF/HF比值与PRPS之间呈负相关。有心理因素组的PRPS和POPS较高，未刺激唾液流速、刺激唾液流速和LF/HF比值较低，无心理因素组则相反。副交感神经组报告的PRPS和POPS较高，口干症状发生率也较高。这可能归因于心理因素在BMS（一种功能性疼痛障碍）中的作用。基于LF/HF比值的不同临床特征表明，LF/HF比值可能作为诊断或预测BMS患者预后的重要指标。
