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从尿路上皮信号传递到体验与膀胱相关的感觉。

From urothelial signalling to experiencing a sensation related to the urinary bladder.

机构信息

Departments of Medicine and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

出版信息

Acta Physiol (Oxf). 2013 Jan;207(1):34-9. doi: 10.1111/apha.12011. Epub 2012 Oct 30.

DOI:10.1111/apha.12011
PMID:23110490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4034264/
Abstract

The mechanisms underlying bladder sensation and the way we experience sensations during normal voiding and in pathology is complex and not well understood. During storage and emptying, mechanical changes occurring in number of cell types within the bladder wall (i.e. the uroepithelium and bladder afferents) can have a major influence on our sensory systems. In this review, we discuss bladder sensation with a focus on coding events in the periphery.

摘要

膀胱感觉的机制以及我们在正常排尿和病理状态下感知感觉的方式非常复杂,目前尚未完全理解。在储存和排空过程中,膀胱壁内多种细胞类型(即尿路上皮和膀胱传入神经)发生的机械变化可能会对我们的感觉系统产生重大影响。在这篇综述中,我们重点讨论了膀胱感觉,特别是对周围编码事件的讨论。

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本文引用的文献

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Use of functional imaging to monitor central control of voiding in humans.使用功能成像技术监测人类排尿的中枢控制。
Handb Exp Pharmacol. 2011(202):81-97. doi: 10.1007/978-3-642-16499-6_5.
2
Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment.一氧化氮对丙烯醛处理大鼠膀胱初级传入活动的影响。
Eur Urol. 2011 Feb;59(2):264-71. doi: 10.1016/j.eururo.2010.10.035. Epub 2010 Oct 26.
3
Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen.
Advanced therapeutic directions to treat the underactive bladder.
治疗膀胱过度活动症的先进治疗方向。 (注:原文中“underactive bladder”表述有误,正确的应该是“overactive bladder”,上述译文是按照纠正后的正确内容翻译)
Int Urol Nephrol. 2014 Sep;46 Suppl 1:S35-44. doi: 10.1007/s11255-014-0809-8. Epub 2014 Sep 20.
4
Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function.膀胱感觉生理学:神经活性化合物和受体、感觉转导器以及源自靶组织的生长因子作为改善功能的靶点。
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15;306(12):R869-78. doi: 10.1152/ajpregu.00030.2014. Epub 2014 Apr 23.
对苯佐卡因对大鼠膀胱初级传入活动的影响,并与利多卡因和对乙酰氨基酚进行比较。
Neurourol Urodyn. 2010 Nov;29(8):1445-50. doi: 10.1002/nau.20886.
4
Corticotropin-releasing factor signaling and visceral response to stress.促肾上腺皮质素释放因子信号转导与内脏对应激的反应。
Exp Biol Med (Maywood). 2010 Oct;235(10):1168-78. doi: 10.1258/ebm.2010.009347.
5
Comparison of the effects of oestrogen deficiency and old age on primary bladder afferent activity and voiding behaviour in the ageing female rat.比较雌激素缺乏和衰老对老年雌性大鼠初级膀胱传入活动和排尿行为的影响。
BJU Int. 2011 Jul;108(2 Pt 2):E10-6. doi: 10.1111/j.1464-410X.2010.09689.x. Epub 2010 Sep 28.
6
The postmenopausal bladder.绝经后的膀胱
Menopause Int. 2010 Jun;16(2):74-80. doi: 10.1258/mi.2010.010020.
7
Effects of intravesical instillation of ATP on rat bladder primary afferent activity and its relationship with capsaicin-sensitivity.膀胱内滴注三磷酸腺苷对大鼠膀胱初级传入活动的影响及其与辣椒素敏感性的关系。
Neurourol Urodyn. 2011 Jan;30(1):163-8. doi: 10.1002/nau.20940. Epub 2010 Jul 21.
8
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Neurourol Urodyn. 2010 Apr;29(4):598-602. doi: 10.1002/nau.20914.
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Investigating afferent nerve activity from the lower urinary tract: highlighting some basic research techniques and clinical evaluation methods.研究下尿路传入神经活动:强调一些基础研究技术和临床评估方法。
Neurourol Urodyn. 2010;29(1):56-62. doi: 10.1002/nau.20776.
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