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健康猫的血浆乳酸测量

Plasma lactate measurements in healthy cats.

作者信息

Redavid Lesleigh A, Sharp Claire R, Mitchell Mark A, Beckel Nicole F

机构信息

New England Animal Medical Center, West Bridgewater, MA 02379, USA.

出版信息

J Vet Emerg Crit Care (San Antonio). 2012 Oct;22(5):580-7. doi: 10.1111/j.1476-4431.2012.00801.x.

DOI:10.1111/j.1476-4431.2012.00801.x
PMID:23110571
Abstract

OBJECTIVES

The primary objective was to determine if venous plasma lactate is affected by struggling during venipuncture in clinically normal, healthy cats. Additional objectives were to evaluate the effects of venipuncture site, age, sex, and time (0-24 h) on plasma lactate concentrations in healthy cats.

DESIGN

Prospective clinical study.

SETTING

Private veterinary referral center.

ANIMALS

Twenty-one healthy, privately owned, sexually altered, adult cats.

INTERVENTIONS

Blood was collected via jugular or medial saphenous venipuncture at the time of study entry and at 6 and 24 hours later.

MEASUREMENTS AND MAIN RESULTS

In healthy cats, there were no significant differences in lactate concentrations statified by degree of struggling at time 0 (P = 0.33), time 6 (P = 0.23), or at time 24 (P = 0.41), venipuncture site (P = 0.58), age (P = 0.62), sex (P = 0.06), or time (P = 0.13). Most cats had mild to moderate struggling scores. Venous plasma lactate concentrations for this group of healthy adult cats had a mean of 1.63 mmol/L; 95% CI: 1.34-1.92, SD: 0.62, and a minimum-maximum range of 0.37-2.81 mmol/L.

CONCLUSIONS

The occurrence of mild to moderate struggling during venipuncture, venipuncture site, age, sex, and time did not affect plasma lactate concentrations in this group of healthy cats. Our results suggest that plasma lactate can be reliably measured in cats. Further studies are warranted in sick cats to determine if plasma lactate measurements can be utilized as a diagnostic or prognostic biomarker.

摘要

目的

主要目的是确定在临床正常、健康的猫进行静脉穿刺时挣扎是否会影响静脉血浆乳酸水平。其他目的是评估静脉穿刺部位、年龄、性别和时间(0 - 24小时)对健康猫血浆乳酸浓度的影响。

设计

前瞻性临床研究。

地点

私立兽医转诊中心。

动物

21只健康、 privately owned、已绝育的成年猫。

干预措施

在研究开始时以及6小时和24小时后通过颈静脉或隐静脉穿刺采集血液。

测量和主要结果

在健康猫中,按0小时(P = 0.33)、6小时(P = 0.23)或24小时(P = 0.41)时的挣扎程度、静脉穿刺部位(P = 0.58)、年龄(P = 0.62)、性别(P = 0.06)或时间(P = 0.13)分层的乳酸浓度无显著差异。大多数猫的挣扎评分轻度至中度。这组健康成年猫的静脉血浆乳酸浓度平均为1.63 mmol/L;95%可信区间:1.34 - 1.92,标准差:0.62,最小 - 最大范围为0.37 - 2.81 mmol/L。

结论

在这组健康猫中,静脉穿刺时轻度至中度挣扎的发生、静脉穿刺部位、年龄、性别和时间均未影响血浆乳酸浓度。我们的结果表明猫的血浆乳酸可以可靠地测量。有必要对患病猫进行进一步研究,以确定血浆乳酸测量是否可作为诊断或预后生物标志物。

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