猫急性动脉血栓栓塞症的黏弹性凝血监测参数。
Viscoelastic coagulation monitoring parameters in cats with acute arterial thromboembolism.
机构信息
Foster Hospital for Small Animals at Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA.
Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, USA.
出版信息
J Vet Intern Med. 2024 Jul-Aug;38(4):2045-2051. doi: 10.1111/jvim.17050. Epub 2024 May 15.
BACKGROUND
Hypercoagulability has been documented in cats with cardiac disease. However, hemostatic parameters, including viscoelastic coagulation monitoring (VCM) have not been reported in cats with arterial thromboembolism (ATE).
HYPOTHESIS/OBJECTIVES: Compare VCM parameters in cats with acute cardiogenic ATE and in control cats.
ANIMALS
Sixteen cats with ATE and 30 control cats.
METHODS
Multicenter university-based prospective study. Cardiogenic ATE was diagnosed based on physical examination and by ultrasonographically-diagnosed left atrial enlargement. Viscoelastic coagulation monitor analysis, CBC, serum biochemistry profile and coagulation profile were performed at admission in cats with ATE. Analysis from healthy control cats was performed using blood collected by direct venipuncture. Our objective was comparison of VCM parameters clot time (CT), clot formation time (CFT), alpha angle (Angle), maximum clot formation (MCF), amplitude at 10 and 20 minutes (A10 and A20, respectively) and clot lysis index at 30 and 45 minutes (LI30 and LI45, respectively) between ATE and control cats.
RESULTS
Cats with ATE had a decreased angle compared to control cats, with a median (range) of 43° (30-48°) compared to 47° (14-59°; P = .01). The parameters A10, A20 and MCF were decreased in ATE cats compared to control cats with a median (range) of 19 units (8-32) compared to 22 units (6-38), 24.5 units (11-40) compared to 29 units (10-47) and 29.5 units (13-44) compared to 33.5 units (14-53), respectively (P = .01, .01 and .01, respectively). The parameters CT, CFT, LI30 and LI45 were similar between groups (P = .22, .09, .62 and .34, respectively).
CONCLUSIONS AND CLINICAL IMPORTANCE
Cats with cardiogenic ATE cats have VCM parameters consistent with hypocoagulability compared with healthy cats.
背景
已有研究证明患有心脏病的猫存在高凝状态。然而，猫动脉血栓栓塞（ATE）患者的止血参数，包括黏弹性凝血监测（VCM）尚未有报道。
假设/目的：比较急性心源性 ATE 猫和对照组猫的 VCM 参数。
动物
16 只 ATE 猫和 30 只对照组猫。
方法
多中心、大学为基础的前瞻性研究。根据体格检查和超声诊断的左心房扩大诊断心源性 ATE。ATE 猫入院时进行黏弹性凝血监测分析、全血细胞计数、血清生化分析和凝血分析。健康对照组猫通过直接静脉穿刺采集血液进行分析。我们的目的是比较 ATE 猫和对照组猫 VCM 参数的凝血时间（CT）、凝血形成时间（CFT）、α角（Angle）、最大凝血形成（MCF）、第 10 分钟和 20 分钟的振幅（A10 和 A20）以及第 30 分钟和 45 分钟的凝块溶解指数（LI30 和 LI45）。
结果
与对照组猫相比，ATE 猫的角降低，中位数（范围）为 43°（30-48°），而对照组猫的角为 47°（14-59°；P=0.01）。与对照组猫相比，ATE 猫的 A10、A20 和 MCF 降低，中位数（范围）分别为 19 单位（8-32）、24.5 单位（11-40）和 29.5 单位（13-44），而对照组猫的分别为 22 单位（6-38）、29 单位（10-47）和 33.5 单位（14-53）（P=0.01、0.01 和 0.01）。CT、CFT、LI30 和 LI45 两组间无差异（P=0.22、0.09、0.62 和 0.34）。
结论和临床意义
与健康猫相比，患有心源性 ATE 的猫的 VCM 参数存在低凝状态。
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