Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Am J Cardiol. 2013 Jan 15;111(2):291-300. doi: 10.1016/j.amjcard.2012.09.029. Epub 2012 Oct 27.
Left bundle branch block (LBBB) causes an abnormal pattern of cardiac activation and affects regional myocardial function. Although recognition of LBBB on the surface electrocardiogram is straightforward, dissecting its effect on patient treatment and outcome can be more challenging. The altered pattern of cardiac activation in LBBB causes electrical and mechanical ventricular dyssynchrony, influences ischemia detection on the surface electrocardiogram, and affects stress testing and imaging modalities dependent on wall motion and thickening. Restoration of synchrony by biventricular pacing can improve symptoms and longevity in carefully selected patients. The diagnostic, prognostic, and therapeutic implications of LBBB across this spectrum are discussed in this review.
左束支传导阻滞（LBBB）导致心脏激活的异常模式，并影响局部心肌功能。虽然在体表心电图上识别 LBBB 很简单，但剖析其对患者治疗和预后的影响可能更具挑战性。LBBB 中心脏激活模式的改变导致电和机械性心室不同步，影响体表心电图上的缺血检测，并影响依赖于壁运动和增厚的应激试验和成像方式。双心室起搏恢复同步性可以改善精心挑选的患者的症状和寿命。本综述讨论了 LBBB 在这一范围内的诊断、预后和治疗意义。
