Rettura G, Padawer J, Barbul A, Levenson S M, Seifter E
JPEN J Parenter Enteral Nutr. 1979 Nov-Dec;3(6):409-16. doi: 10.1177/014860717900300601.
Arginine supplements were given to 6 week old CBA mice beginning 3 days prior to inoculation with a murine sarcoma virus, the Moloney Sarcoma Virus (MSV). Although the basal diet contained 1.8% arginine and was therefore not arginine-deficient, supplementation of the diet and the drinking water with 0.5% arginine HCl reduced tumor incidence, lengthened the latency period, decreased tumor size, and hastened tumor regression. Arginine also increased thymic weight and cellularity in normal and in MSV-inoculated mice. The antitumor action of arginine may be related to its effect on the thymus.
在给6周龄的CBA小鼠接种莫洛尼肉瘤病毒（MSV）这种鼠肉瘤病毒前3天开始给予精氨酸补充剂。尽管基础饮食含有1.8%的精氨酸，因此不存在精氨酸缺乏的情况，但在饮食和饮用水中补充0.5%的盐酸精氨酸可降低肿瘤发生率、延长潜伏期、减小肿瘤大小并加速肿瘤消退。精氨酸还增加了正常小鼠和接种MSV小鼠的胸腺重量和细胞数量。精氨酸的抗肿瘤作用可能与其对胸腺的影响有关。
