Seifter E, Rettura G, Padawer J, Levenson S M
J Natl Cancer Inst. 1982 May;68(5):835-40.
Decreased tumor frequency, increased latent period, and increased rate of tumor regression were observed in male inbred CBA/J mice fed supplemental beta-carotene before and/or after they were inoculated with the Moloney sarcoma virus. When beta-carotene feeding was begun after tumors were already present, it markedly increased the rate of tumor regression. beta-Carotene minimized the virus-induced thymus gland involution that accompanies tumor growth, and this action on the thymus gland was believed to underlie part of beta-carotene's antitumor activity. The basal diet, a standard commercial mouse chow containing more vitamin A than the National Research Council recommends as a daily allowance for rodents, supported normal growth, reproduction, and longevity of normal mice. The work reported here is the first demonstration of the antitumor action of beta-carotene in mice inoculated with an oncogenic virus.
在接种莫洛尼肉瘤病毒之前和/或之后喂食补充β-胡萝卜素的雄性近交CBA/J小鼠中，观察到肿瘤发生率降低、潜伏期延长和肿瘤消退率增加。当在肿瘤已经出现后开始喂食β-胡萝卜素时，它显著提高了肿瘤消退率。β-胡萝卜素使伴随肿瘤生长的病毒诱导的胸腺萎缩最小化，并且认为这种对胸腺的作用是β-胡萝卜素抗肿瘤活性的部分基础。基础饮食是一种标准的商业小鼠饲料，其维生素A含量高于美国国家研究委员会建议的啮齿动物每日摄入量，能维持正常小鼠的正常生长、繁殖和寿命。此处报道的研究首次证明了β-胡萝卜素对接种致癌病毒的小鼠具有抗肿瘤作用。
