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维生素A对接种莫洛尼肉瘤病毒和痘病毒小鼠的解热及抗病毒作用

Antipyretic and antiviral action of vitamin A in Moloney sarcoma virus- and poxvirus-inoculated mice.

作者信息

Seifter E, Rettura G, Padawer J, Demetriou A A, Levenson S

出版信息

J Natl Cancer Inst. 1976 Aug;57(2):355-9. doi: 10.1093/jnci/57.2.355.

DOI:10.1093/jnci/57.2.355
PMID:187770
Abstract

Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemented with vitamin A palmitate (150,000 U/kg) were inoculated with either the Moloney strain of murine sarcoma virus (M-MuSV) or poxvirus. Central body temperature was measured daily. Both viruses elicited fevers, but the fevers were less pronounced and of shorter duration in the mice ingesting the vitamin A-supplemented diet. Palpable M-MuSV-induced tumors appeared later, were less frequent, grew more slowly, and were resorbed sooner in the mice fed the vitamin A supplement. Similarly, in these mice the appearance of pox lesions was delayed, their numbers reduced, and their disappearance hastened.

摘要

给六周大的雄性CBA/J小鼠喂食市售粉状实验室饲料或添加了棕榈酸视黄醇(150,000 U/kg)的相同饲料,然后用莫洛尼鼠肉瘤病毒(M-MuSV)毒株或痘病毒接种。每天测量核心体温。两种病毒都引发了发热,但在摄入补充了维生素A的饮食的小鼠中,发热不那么明显,持续时间也更短。在喂食维生素A补充剂的小鼠中,可触及的M-MuSV诱导的肿瘤出现得更晚,频率更低,生长更慢,并且更快被吸收。同样,在这些小鼠中,痘疹病变的出现延迟,数量减少,消失加快。

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Differential modulating effects of retinoic acid on interferon antiviral activity.
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