免疫抑制会增加无进行性多灶性白质脑病患者大脑中的 JC 多瘤病毒大 T 抗原 DNA 载量。

Immunosuppression increases JC polyomavirus large T antigen DNA load in the brains of patients without progressive multifocal leukoencephalopathy.

机构信息

Department of Medicine, Monash University, Seven, Alfred Centre, Alfred Hospital, Commercial Rd, Melbourne, VIC 3004, Australia.

出版信息

J Infect Dis. 2013 Jan 1;207(1):133-6. doi: 10.1093/infdis/jis668. Epub 2012 Oct 30.

DOI:10.1093/infdis/jis668

PMID:23112281

Abstract

The relationship between latent JC polyomavirus (JCV) infection and progressive multifocal leukoencephalopathy (PML) remains unclear. In this study, JCV DNA was quantified by real-time polymerase chain reaction (qPCR) in brain and kidney tissue from patients without PML. Immunosuppressed patients had significantly higher JCV DNA levels in brain, compared with immunocompetent patients (P = .001). An inverse relationship was observed between CD4(+) T-cell counts and qPCR-determined brain JCV load among patients with HIV infection (r(2) = -0.9; P = .01; n = 7). Higher kidney JCV DNA load was strongly associated with higher brain JCV DNA load (Spearman ρ = 0.65; P = .004; n = 18). These findings highlight the importance of latent JVC brain infection to the pathogenesis of PML.

摘要

潜伏性 JC 多瘤病毒（JCV）感染与进行性多灶性白质脑病（PML）之间的关系尚不清楚。在这项研究中，通过实时聚合酶链反应（qPCR）对无 PML 患者的脑和肾组织中的 JCV DNA 进行了定量。与免疫功能正常的患者相比，免疫抑制患者的脑 JCV DNA 水平显著升高（P =.001）。在 HIV 感染患者中，观察到 CD4(+)T 细胞计数与 qPCR 确定的脑 JCV 载量呈负相关（r(2) = -0.9；P =.01；n = 7）。较高的肾 JCV DNA 载量与较高的脑 JCV DNA 载量密切相关（Spearman ρ = 0.65；P =.004；n = 18）。这些发现强调了潜伏性 JVC 脑感染对 PML 发病机制的重要性。