Zhou H, Guo Zr, Hu Xs, Yu Lg, Xu Bh, Wu M, Zhou Zy, Yang C
The Center for Disease Control and Prevention of Suzhou Industry Park, SuZhou, 215021,China ; Dept. of Epidemiology, School of Public Health, Soochow University, SuZhou, 215123, China.
Iran J Public Health. 2012;41(4):26-34. Epub 2012 Apr 30.
Metabolic syndrome (MS) is the syndrome closely related to cardiovascular disease (CVD) risk factors. Few prospective studies have compared the impact of dynamic changes of MS on the development of cardiovascular diseases (CVD).
Overall, 3461 subjects were recruited from a cohort study on Prevention of Multiple Metabolic disorders and MS in Jiangsu of China (PMMJS) with a follow up of 3.8 years. The associations between the dynamic changes (Difference, the value at first follow-up subtract the value at baseline) of MS, component numbers, components and relative risk (RR) of CVD were analyzed by using Cox regression model.
The total incidence standardized rate of CVD was 2.58%,and the incidence standardized rates of CVD in MS-/follow-up MS-,baseline MS-/follow-up MS+, baseline MS+/follow-up MS- and baseline MS+/follow-up groups were 2.05%,5.01%,1.65% and 4.39% separately. After adjustment confounding factors Difference in FPG, BP and TG have significantly effects on the incidence of CVD.
Difference of MS component numbers had the prediction ability of CVD, but MS groups based on baseline and first follow-up MS and/or non-MS had not. In Chinese, the dynamic change of MS component numbers was a useful predict factor for CVD.
代谢综合征（MS）是一种与心血管疾病（CVD）风险因素密切相关的综合征。很少有前瞻性研究比较MS动态变化对心血管疾病（CVD）发生发展的影响。
总共从中国江苏一项关于多种代谢紊乱和MS预防的队列研究（PMMJS）中招募了3461名受试者，随访时间为3.8年。采用Cox回归模型分析MS的动态变化（差值，首次随访值减去基线值）、组分数量、组分与CVD相对风险（RR）之间的关联。
CVD的总标准化发病率为2.58%，MS-/随访MS-、基线MS-/随访MS+、基线MS+/随访MS-和基线MS+/随访组中CVD的标准化发病率分别为2.05%、5.01%、1.65%和4.39%。调整混杂因素后，空腹血糖（FPG）、血压（BP）和甘油三酯（TG）的差值对CVD发病率有显著影响。
MS组分数量的差值对CVD具有预测能力，但基于基线和首次随访时MS和/或非MS的分组情况则没有。在中国人群中，MS组分数量的动态变化是CVD的一个有用预测因素。
