Traub W H
Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Homburg a.d. Saar, FRG.
Chemotherapy. 1990;36(2):127-35. doi: 10.1159/000238758.
Twenty-four antimicrobial drugs were examined for rapidity of onset and magnitude of bactericidal activity against selected strains of Clostridium perfringens. Ceftriaxone, imipenem, metronidazole, mezlocillin, penicillin G, piperacillin, and teicoplanin reduced colony counts by at least 3 log10 units within 2-4 h after exposure. Clindamycin, fluoroquinolones, josamycin, and tetracycline caused delayed kill (greater than or equal to 99.9% reduction of viable counts at 4-22 h after exposure). Chloramphenicol and rifampin lacked bactericidal activity against 2 of 4 strains, whereas erythromycin, fusidic acid, and fosfomycin (with added glucose-6-phosphate) were merely inhibitory for all 4 strains. Imipenem and penicillin G were combined with 9 and 12 antimicrobial drugs, respectively. Essentially all drug combinations yielded indifferent effects; only penicillin G plus doxycycline resulted in an antagonistic effect against C. perfringens.
对24种抗菌药物进行了检测，以评估其对所选产气荚膜梭菌菌株的起效速度和杀菌活性强度。头孢曲松、亚胺培南、甲硝唑、美洛西林、青霉素G、哌拉西林和替考拉宁在暴露后2 - 4小时内可使菌落计数至少减少3个对数10单位。克林霉素、氟喹诺酮类、交沙霉素和四环素导致延迟杀菌（暴露后4 - 22小时活菌计数减少大于或等于99.9%）。氯霉素和利福平对4株菌株中的2株缺乏杀菌活性，而红霉素、夫西地酸和磷霉素（添加6 - 磷酸葡萄糖）对所有4株菌株仅具有抑制作用。亚胺培南和青霉素G分别与9种和12种抗菌药物联合使用。基本上所有药物组合均产生无明显作用的效果；只有青霉素G加强力霉素对产气荚膜梭菌产生拮抗作用。
