A型产气荚膜梭菌对23种抗菌药物的敏感性

Susceptibility of Clostridium perfringens type A to 23 antimicrobial drugs.

作者信息

Traub W H, Karthein J, Spohr M

出版信息

Chemotherapy. 1986;32(5):439-45. doi: 10.1159/000238448.

Abstract

A total of 106 strains of Clostridium perfringens type A, that had been isolated very recently from faecal cultures of healthy adults, were examined for susceptibility to 23 antimicrobial drugs (agar dilution method). All strains were susceptible to ampicillin, cefazolin, cefotaxime, cefotetan, cefoxitin, ceftriaxone, ciprofloxacin, fusidic acid, imipenem, metronidazole, mezlocillin, ofloxacin, penicillin G, piperacillin, teicoplanin, and vancomycin. Teicoplanin and imipenem were the most active, whereas fosfomycin and tetracycline were the least active drugs. Three of the 106 strains revealed multiple drug resistance against clindamycin, erythromycin, josamycin, tetracycline, and, in one instance, against chloramphenicol.

摘要

对最近从健康成年人粪便培养物中分离出的106株A型产气荚膜梭菌进行了23种抗菌药物敏感性检测（琼脂稀释法）。所有菌株对氨苄西林、头孢唑林、头孢噻肟、头孢替坦、头孢西丁、头孢曲松、环丙沙星、夫西地酸、亚胺培南、甲硝唑、美洛西林、氧氟沙星、青霉素G、哌拉西林、替考拉宁和万古霉素敏感。替考拉宁和亚胺培南活性最强，而磷霉素和四环素活性最弱。106株菌株中有3株对克林霉素、红霉素、交沙霉素、四环素耐药，其中1株还对氯霉素耐药。