Traub W H
Chemotherapy. 1986;32(1):59-67. doi: 10.1159/000238389.
Penicillin G and imipenem (N-formimidoyl thienamycin) in vitro were the most active of twelve examined antimicrobial drugs against clinical and fecal isolates of Clostridium perfringens type A. However, vancomycin and fosfomycin, which revealed suboptimal in vitro bactericidal activity, proved as efficacious as penicillin G and imipenem in an experimental mode of murine gas gangrene. Thus, conventional in vitro tests were not uniformly predictive for in vivo (murine) chemotherapeutic efficacy.
在针对A型产气荚膜梭菌临床和粪便分离株进行检测的12种抗菌药物中，青霉素G和亚胺培南（N-甲酰亚胺硫霉素）在体外表现出最强的活性。然而，体外杀菌活性欠佳的万古霉素和磷霉素，在小鼠气性坏疽实验模型中却证明与青霉素G和亚胺培南一样有效。因此，传统的体外试验并不能一致地预测体内（小鼠）化疗疗效。
