Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, China.
J Am Chem Soc. 2012 Nov 14;134(45):18522-5. doi: 10.1021/ja308357y. Epub 2012 Nov 5.
A novel chiral surfactant-type catalyst is developed. Micelles formed in water by association of the catalysts themselves, and this was confirmed by TEM analyses. Asymmetric transfer hydrogenation of aliphatic ketones catalyzed by the chiral metallomicellar catalyst gave good to excellent conversions and remarkable stereoselectivities (up to 95% ee). Synergistic effects between the metal-catalyzed center and the hydrophobic microenvironment of the core in the metallomicelle led to high enantioselectivities.
开发了一种新型手性表面活性剂型催化剂。通过 TEM 分析证实，这些催化剂本身在水中通过缔合形成胶束。手性金属胶束催化剂催化脂肪族酮的不对称转移氢化反应，转化率和对映选择性都很好（高达 95%ee）。金属催化中心与金属胶束内核的疏水环境之间的协同作用导致了高对映选择性。
