新型可循环离子标记二茂铁-钌催化剂体系用于芳香酮的不对称氢化反应
Asymmetric hydrogenation of aromatic ketones by new recyclable ionic tagged ferrocene-ruthenium catalyst system.
作者信息
Xu Di, Zhou Zhi-Ming, Dai Li, Tang Li-Wei, Zhang Jun
机构信息
R&D Center for Pharmaceuticals, School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, PR China.
R&D Center for Pharmaceuticals, School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, PR China; State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, PR China.
出版信息
Bioorg Med Chem Lett. 2015 May 1;25(9):1961-4. doi: 10.1016/j.bmcl.2015.03.023. Epub 2015 Mar 14.
Newly developed ferrocene-oxazoline-phosphine ligands containing quaternary ammonium ionic groups exhibited excellent catalytic performance for the ruthenium-catalyzed hydrogenation of aromatic ketonic substrates to give chiral secondary alcohols with high levels of conversions and enantioselectivities. Simple manipulation process, water tolerance, high activity and good recyclable property make this catalysis practical and appealing.
新开发的含季铵离子基团的二茂铁-恶唑啉-膦配体对钌催化的芳香族酮底物氢化反应表现出优异的催化性能，能以高转化率和对映选择性得到手性仲醇。简单的操作过程、耐水性、高活性和良好的可循环使用性能使得这种催化反应具有实用性和吸引力。
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