Does the adult stroma contain stem cells?

It is well accepted that adult mesenchymal stromal cells (MSCs) comprise subpopulations of cells sharing common phenotypical and functional properties. However, there is emerging evidence that MSC subpopulations may also feature distinct characteristics. This chapter focuses on MSC subpopulations reflecting their possible stem cell properties relative to defined pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs). This attempt at an ontogenetic reflection on MSCs can be useful for both basic and translational research in the field.