Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA, 94305-5487, USA,
Adv Biochem Eng Biotechnol. 2013;129:177-89. doi: 10.1007/10_2012_160.
It is well accepted that adult mesenchymal stromal cells (MSCs) comprise subpopulations of cells sharing common phenotypical and functional properties. However, there is emerging evidence that MSC subpopulations may also feature distinct characteristics. This chapter focuses on MSC subpopulations reflecting their possible stem cell properties relative to defined pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs). This attempt at an ontogenetic reflection on MSCs can be useful for both basic and translational research in the field.
人们普遍认为，成人间充质基质细胞 (MSCs) 由具有共同表型和功能特性的细胞亚群组成。然而，越来越多的证据表明，MSC 亚群也可能具有不同的特征。本章重点介绍反映 MSC 可能的干细胞特性的 MSC 亚群，这些特性相对于胚胎干细胞 (ESCs) 或诱导多能干细胞 (iPSCs) 等定义明确的多能干细胞 (PSCs)。这种对 MSC 的胚胎发生反射的尝试对该领域的基础研究和转化研究都可能是有用的。
