Khakshoor Hamid, Moshirfar Majid, Simpson Rachel G, Gharaee Hamid, Vejdani Amir H, Christiansen Steven M, Edmonds Jason N, Behunin Nicholas L
Mashhad University of Medical Sciences, Department of Ophthalmology, Mashad, Iran;
Clin Ophthalmol. 2012;6:1719-22. doi: 10.2147/OPTH.S36611. Epub 2012 Oct 26.
This observational case report describes the development of bilateral Mooren-like ulcers in a patient with anesthetic keratopathy. A 42-year-old man with a recent history of minor eye trauma and pain self-treated with tetracaine eye drops presented with complaints of acutely worsening vision and severe pain bilaterally. His visual acuity at presentation was limited to hand motion. Slit-lamp examination revealed bilateral epithelial defects at the center of the cornea, and an area of stromal infiltration and thinning with an undermining leading edge resembling a Mooren's ulcer in both eyes. Corneal haze and hypopyon were visible. Anesthetic use was halted immediately and the patient was started on prednisolone and mycophenolate mofetil (Cellcept(®)), after which visual acuity gradually improved and pain decreased. Despite improvement of symptoms, residual epithelial defects remained, and the patient was ultimately treated with keratoplasty for recovery of vision. We suggest that anesthetic keratopathy should be included in the differential diagnosis for any patient presenting with ring-shaped stromal infiltrates or nonhealing epithelial defects.
本观察性病例报告描述了一名患有麻醉性角膜病变的患者双侧类莫伦溃疡的发展情况。一名42岁男性,近期有轻微眼外伤史,曾自行使用丁卡因滴眼液治疗疼痛,现出现双侧视力急剧下降和剧痛的主诉。就诊时其视力仅为手动。裂隙灯检查显示双侧角膜中央上皮缺损,双眼基质浸润及变薄区域伴有潜行性前缘,类似莫伦溃疡。可见角膜混浊和前房积脓。立即停用麻醉药,并开始给予泼尼松龙和霉酚酸酯(骁悉®)治疗,之后视力逐渐改善,疼痛减轻。尽管症状有所改善,但仍残留上皮缺损,患者最终接受角膜移植手术以恢复视力。我们建议,对于任何出现环形基质浸润或上皮缺损不愈合的患者,鉴别诊断时应考虑麻醉性角膜病变。