Bradoo R A, Nerurkar N K, Mhapankar J B, Patil S F, Kute D G
Senior Resident Department of ENT, L.T.M. Medical College & Hospital, Sion, 400022 Mumbai.
Indian J Otolaryngol Head Neck Surg. 2000 Apr;52(2):151-8. doi: 10.1007/BF03000335.
This open, prospective study was carried out in 29 outpatients of vertigo with Betahistine treatment at a dose of 16 mg three times daily far a maximum treatment period of 6 weeks or earlier until remission of vertigo attacks. The evaluations were carried out based on three parameters such as frequency, duration, and severity of vertigo attacks. Betahistino showed a significant improvement in the three parameters of frequency, duration and severity of vertigo attacks. Associated symptoms such as tinnitus, nausea, vomiting, headache, faintness showed a significant improvement with the therapy. Subgroup analysis showed a significant improvement of patients with severe and incapacitating verlign attaeks at baseline. Thus, this study proves excellent efficacy and goad tolerability of Betahistine as an anti-vertigo drug at a dose of 16 mg three times daily and gives a new insight for controlling acute or severe vertigo attacks without causing sedation.
这项开放性前瞻性研究纳入了29例眩晕门诊患者,给予倍他司汀治疗,剂量为每日3次,每次16mg,最长治疗期为6周,或在眩晕发作缓解前提前结束治疗。评估基于眩晕发作的频率、持续时间和严重程度这三个参数进行。倍他司汀在眩晕发作的频率、持续时间和严重程度这三个参数上均显示出显著改善。耳鸣、恶心、呕吐、头痛、头晕等相关症状在治疗后也有显著改善。亚组分析显示,基线时患有严重且致残性眩晕发作的患者有显著改善。因此,本研究证明了倍他司汀作为一种抗眩晕药物,每日3次,每次16mg的剂量具有优异的疗效和良好的耐受性,并为控制急性或严重眩晕发作且不引起镇静作用提供了新的见解。