Oosterveld W J
Clin Otolaryngol Allied Sci. 1987 Apr;12(2):131-5. doi: 10.1111/j.1365-2273.1987.tb00175.x.
The effect of betahistine on vestibular nystagmus induced by means of a torsion swing was tested in 10 subjects. Each individual received, in a randomized double-blind study, 3 different single oral dosages of betahistine (8, 16 and 32 mg) on 3 different occasions. Electronystagmographic tracings were taken at different time-intervals after drug intake. At 3-4 hours after a dose of 8 mg betahistine the nystagmus duration was reduced by 35%, after 16 mg betahistine by 48% and after 32 mg betahistine by 59% (mean values). All these differences in dose-response are highly significant (P less than 0.0005). It can be concluded from these results, that a dose of 3 X 8 mg or 3 X 16 mg betahistine daily will be efficacious in maintenance treatment of vertigo, and a dose of 3 X 24 mg betahistine daily will have even more effect.
在10名受试者身上测试了倍他司汀对通过扭转摆动诱发的前庭眼球震颤的影响。在一项随机双盲研究中，每位受试者在3个不同的场合接受3种不同的单次口服倍他司汀剂量（8、16和32毫克）。在服药后的不同时间间隔进行眼震电图描记。服用8毫克倍他司汀后3 - 4小时，眼球震颤持续时间缩短了35%，服用16毫克倍他司汀后缩短了48%，服用32毫克倍他司汀后缩短了59%（平均值）。所有这些剂量反应差异均具有高度显著性（P小于0.0005）。从这些结果可以得出结论，每日剂量为3×8毫克或3×16毫克的倍他司汀在眩晕的维持治疗中有效，而每日剂量为3×24毫克的倍他司汀效果更佳。
